Brown and white adipose tissue lipid composition in three successive progenies of rats: Effects of ethanol exposure

E. Tavares, Ana Gómez‐Tubío, M. Murillo, O. Carreras
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引用次数: 2

Abstract

The effect of ethanol exposure on the fatty acid composition of brown and white adipose tissue in three successive rat progenies at the end of an experimental period (24 weeks) was studied. Ethanol‐treated rats received a standard rat chow diet and 5, 10 and 15% ethanol in the ad libitum drinking fluid over 3 successive weeks. Then a concentration of 20% ethanol was maintained for 5 additional weeks up to the end of the experimental period. The males and females in the ethanol treated group were mated to obtain the 1st generation of offspring. Then female and male rats from the 1st generation were mated to obtain the 2nd generation. Finally, males and females from the 2nd generation were mated to obtain the 3rd generation of ethanol treated rats. Another group served as control and received only water and a standard rat chow diet. The control group was handled in the same way as the other experimental groups. In the 1st and 2nd generations the percentage of stearic acid (18:0) decreased and palmitoleic (16:ln7) and oleic acid (18:ln9) increased in both adipose tissues of ethanol‐treated rats with respect to control. Additionally, n‐3 and n‐6 series were reduced both in brown and white adipose tissues. In the 3rd generation the fatty acid composition of the white adipose tissue was similar to that of control rats. Thus, no significant difference in essential fatty acids and oleic acid (18:ln9) were found. However, the fatty acid composition of the brown adipose tissue, in the 3rd generation, was similar to that observed in the 1st and 2nd generation. Thus, a decrease in essential fatty acids and an increase in oleic acid (18:ln9) was found. This suggests adaptation to ethanol consumption during successive progenies in white adipose tissue. However, in brown adipose tissue the values indicate a triglyceride storing during the thermogenesis, which is more important to newborns.
三个连续后代大鼠棕色和白色脂肪组织脂质组成:乙醇暴露的影响
研究了乙醇暴露对连续3个大鼠子代24周后棕色和白色脂肪组织脂肪酸组成的影响。乙醇处理的大鼠连续3周接受标准大鼠饲料和随意饮用液体中含有5%、10%和15%乙醇。然后再维持20%乙醇浓度5周至实验结束。乙醇处理组雄性和雌性进行交配,得到第一代后代。将第1代雌雄大鼠进行交配,得到第2代。最后,将第二代雄性和雌性进行交配,得到第三代乙醇处理大鼠。另一组作为对照,只接受水和标准鼠粮。对照组的处理方法与其他实验组相同。在第一代和第二代,与对照组相比,乙醇处理大鼠脂肪组织中硬脂酸(18:0)的百分比下降,棕榈油酸(16:7)和油酸(18:9)的百分比增加。此外,n - 3和n - 6系列在棕色和白色脂肪组织中均减少。第3代白色脂肪组织脂肪酸组成与对照大鼠相似。因此,必需脂肪酸和油酸(18:ln9)无显著差异。然而,第3代棕色脂肪组织的脂肪酸组成与第1代和第2代相似。因此,必需脂肪酸的减少和油酸的增加(18:9)被发现。这表明在白色脂肪组织的连续后代中对乙醇消耗的适应。然而,在棕色脂肪组织中,该值表明在产热过程中储存甘油三酯,这对新生儿更重要。
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