Efficacy of Anticonvulsant Administration as Seizure Prophylactic Therapy in Traumatic Brain Injury Patients

IF 0.7 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Filippo David Tamara
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Abstract

Traumatic brain injury (TBI) is a non-degenerative, non-congenital disorder of the brain that occurs due to external mechanics that can cause permanent or temporary impairment of cognitive, physical and psychosocial functions. Based on the 2018 Basic Health Research (Riskesdas) data, the prevalence of head injuries in Indonesia is 11.9%. Seizures after head injury result in secondary brain damage and seizure prophylaxis is only recommended in patients with TBI during the first seven days. This study was designed to assess the efficacy of anticonvulsants as prophylactic therapy in patients with TBI in Indonesia. The research method used was a literature review that was searched using Google Scholar, Pubmed, Medline, Ebsco, Hindawi, ScienceDirect, and Cochrane, published in the last ten years. After obtaining the appropriate literature, the manuscript is written. The results showed that prophylactic anticonvulsants such as Phenytoin could reduce the incidence of early posttraumatic seizures (PTS) in patients with TBI compared to placebo. Another study also stated that giving anticonvulsants (Carbamazepine, Phenobarbital, Phenytoin, Levetiracetam and Valproate) in preventing early PTS showed effective results in TBI when compared to placebo. So, it can be concluded, based on the literature search conducted, anticonvulsants are proven to be able to prevent PTS, with the recommendation of drug choice being Phenytoin.
抗惊厥药预防外伤性脑损伤患者癫痫发作的疗效
外伤性脑损伤(TBI)是一种非退行性、非先天性的脑部疾病,由外部力学引起,可导致认知、身体和社会心理功能永久性或暂时性损伤。根据2018年基本健康研究(Riskesdas)数据,印度尼西亚的头部受伤发生率为11.9%。脑损伤后癫痫发作可导致继发性脑损伤,仅建议TBI患者在头7天内进行癫痫预防。本研究旨在评估抗惊厥药在印度尼西亚TBI患者中的预防性治疗效果。使用的研究方法是使用Google Scholar、Pubmed、Medline、Ebsco、Hindawi、ScienceDirect和Cochrane检索近十年发表的文献综述。在获得适当的文献资料后,撰写手稿。结果表明,与安慰剂相比,苯妥英等预防性抗惊厥药物可降低TBI患者早期创伤后癫痫发作(PTS)的发生率。另一项研究还表明,与安慰剂相比,使用抗惊厥药物(卡马西平、苯巴比妥、苯妥英、左乙拉西坦和丙戊酸钠)预防早期PTS对TBI有更有效的效果。综上所述,通过文献检索,抗惊厥药物可以预防PTS,推荐选择苯妥英。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Migration Health and Social Care
International Journal of Migration Health and Social Care PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.30
自引率
0.00%
发文量
21
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