High neutrophil/lymphocyte ratio and low lymphocyte percentage are independent risk factors for new-onset CKD

Clinical Immunology Communications Pub Date : 2022-12-01 DOI:10.1016/j.clicom.2022.11.003

Mengyuan Guo , Zhaohui Wang , Rui Yang , Kun Liu , Junchao Zeng , Tianhui An

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Abstract

Chronic kidney disease (CKD) is one of the major public health problems worldwide, and inflammation is a noticeable cause of CKD. A total of 5508 non-CKD patients were enrolled in our prospective study and followed for three years, with 1.25% (n = 69) participants having newonset CKD at the endpoint. After adjustment for potential confounders, we found that High NLR and low LYMPH% are two independent risk factors for new-onset CKD: Compared with the lowest NLR tertile, the multifactor corrected OR (95% CI) of the highest tertile was 2.47(1.20–5.09), P = 0.014; And adjusted OR (95% CI) was 0.31(0.16–0.62) for the highest LYMPH% tertile, P = 0.001. The model constructed with NLR, LYMPH%, and other risk factors had favourable predictive power for new-onset CKD with an AUC of 0.82 (95% CI, 0.76–0.88). Assessment of NLR and LYMPH% may be helpful for early warning of CKD occurrence.

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中性粒细胞/淋巴细胞比值高和淋巴细胞百分比低是新发CKD的独立危险因素

慢性肾脏疾病(CKD)是世界范围内主要的公共卫生问题之一，炎症是CKD的一个显著原因。我们的前瞻性研究共纳入了5508名非CKD患者，随访3年，其中1.25% (n = 69)的参与者在终点时患有新发CKD。在对潜在混杂因素进行校正后，我们发现高NLR和低LYMPH%是新发CKD的两个独立危险因素:与最低NLR分位数相比，最高分位数的多因素校正OR (95% CI)为2.47(1.20-5.09)，P = 0.014;最高淋巴百分比的校正OR (95% CI)为0.31(0.16-0.62)，P = 0.001。由NLR、LYMPH%和其他危险因素构建的模型对新发CKD具有良好的预测能力，AUC为0.82 (95% CI, 0.76-0.88)。评估NLR和LYMPH%可能有助于CKD发生的早期预警。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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