Effects of fluoride on primary cultured haemocytes from the marine gastropod Haliotis tuberculata

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-01-03 DOI:10.25431/1824-307X/ISJ.V0I0.1-7

R. Ladhar-Chaabouni, T. Houel, J. Lebel, A. Hamza-Chaffai, A. Serpentini

引用次数: 2

Abstract

As a consequence of human’s activities, fluoride concentration in many aquatic ecosystems is significantly increasing. Nevertheless, little is known about fluoride toxicity to aquatic life. In this study the effect of exposure to different concentrations of sodium fluoride (2, 10, 50, 250 and 1,250 μg mL−1) during 24 h on primary cultured haemocytes of the gastropod Haliotis tuberculata was realized. Results indicate no significant effect of NaF on cell viability, Lysosomal membrane stability, phagocytosis and ROS production at concentrations of 2, 10, 50 and 250 μg mL−1. Nevertheless, lysosomal membrane alterations, a decrease of phagocytosis and morphological changes of H. tuberculata haemocytes were observed at concentration of 1,250 μg mL−1 NaF suggesting a potential impact of NaF at high concentration in the environment.

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氟对海洋腹足动物结核盘藻原代培养血细胞的影响

由于人类的活动，许多水生生态系统中的氟化物浓度正在显著增加。然而，人们对氟化物对水生生物的毒性知之甚少。本研究观察了不同浓度氟化钠(2、10、50、250和1250 μg mL−1)对腹足动物结核盘藻(Haliotis tuberculata)原代培养血细胞的影响。结果表明，在2、10、50和250 μg mL−1浓度下，NaF对细胞活力、溶酶体膜稳定性、吞噬能力和ROS产生均无显著影响。然而，在1,250 μg mL - 1 NaF浓度下，观察到溶酶体膜改变、吞噬减少和结核分枝杆菌血细胞形态学改变，提示环境中高浓度NaF可能会产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.