Public Health Implication of Mycotoxin Contaminated Pawpaw (Carica papaya L) on Sale in Nigerian Markets

International journal of health research and innovation Pub Date : 2012-01-01 DOI:10.4314/IJHR.V5I1

O. Oyeyipo, C. Iwuji, O. Owhoeli

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引用次数: 3

Abstract

Purpose : To evaluate the mycotoxigenic potential of fungi associated with marketed pawpaw in South Southern Nigeria and the public health significance. Methods : Pawpaw fruits with lesions or rots were obtained from three different markets in three different states in South Southern Nigeria. Five genera of moulds (Rhizopus, Aspergillus, Fusarium, Curvularia and Trichoderma) were isolated and used for inoculation of sound pawpaw samples at two wound depths of 5 and 7mm with either single or paired cultures. The resultant isolates were evaluated for mycotoxin production using thin layer chromatography and the mycotoxigenic potential of isolates was assessed by animal feeding trial using albino rats of the wistar strain fed orally with different concentrations of the mycotoxin extracts Results : Mycotoxins were detected from pawpaw samples inoculated with Rhizopus, Aspergillus and Fusarium, before and after autoclaving for 15 min at 121 oC. Wistar rats fed on mycotoxin extracts developed symptoms of neurotoxicity characterized by ascending paralysis, convulsion and respiratory arrest. Conclusion : Most of the fungal isolates in this study showed a great potential for mycotoxin production with associated neurotoxicity which is of concern in public health. Keywords : Fungi, Pawpaw, Mycotoxins, Neurotoxicity, Public health

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受霉菌毒素污染的木瓜在尼日利亚市场销售对公众健康的影响

目的:评价尼日利亚南部市售木瓜相关真菌的产毒潜力及其公共卫生意义。方法:在尼日利亚南部3个不同州的3个不同市场获得病变或腐烂的木瓜果实。分离出5属霉菌(Rhizopus, Aspergillus, Fusarium, Curvularia和Trichoderma)，分别在5和7mm两个伤口深度接种健全木瓜样品，采用单次或成对培养。采用薄层色谱法对分离得到的菌株进行产毒评价，并通过动物饲养试验对wistar菌株的产毒潜力进行评价。结果:接种根霉、曲霉和镰刀菌的木瓜样品，在121℃高压灭菌15 min前后均检测到霉菌毒素。喂食霉菌毒素提取物的Wistar大鼠出现以上升性麻痹、抽搐和呼吸停止为特征的神经毒性症状。结论:本研究发现的大多数真菌分离株具有产生真菌毒素的巨大潜力，并具有相关的神经毒性，这是公共卫生关注的问题。关键词:真菌，木瓜，真菌毒素，神经毒性，公共卫生

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International journal of health research and innovation

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