Evaluation of Diur-08 A Polyherbal Formulation for Diuretic Activity

Abstract

In the present study diuretic activity of Diur-08, a polyherbal formulation was studied. The animals were divided into three groups of six animals each. All the animals received priming dose of 0.9% sodium chloride solution (25 ml/Kg body weight.). The first group served as control and the second group received the standard drug Spiranolactone (20 mg/Kg body weight) in 0.9% sodium chloride solution. The other group received Diur-08 at a dose of 150mg/Kg body weight suspended in 0.9% sodium chloride solution (post oral.).Urine volume was measured for all the groups for 5h. Urinary levels of sodium, potassium and chloride were estimated. Both spironolactone and formulation Diur-08 treated animals shown significant diuretic activity compared to control animals. Also there is significant increase in Na and Cl excretion in treated animals when compared to control animals. We observed a potent diuretic and electrolyte excretion activity of Diur-08 formulation.