Factors related to postoperative prognosis of kidney transplant recipients: A retrospective analysis of 127 patients

Abstract

Objectives

At present, kidney transplant recipients are more likely to suffer from postoperative infection, rejection, or accidental death than general population. This study aims to discuss whether or not certain laboratory testings can predict the postoperative physical recovery in the perioperative period of renal transplant.

Methods

This paper is a retrospective cohort review of 127 patients who received kidney transplantation from January 2013 to November 2017 at the First Affiliated Hospital of Soochow University, China. These patients were classified into three groups: postoperative infection, accidental death and event-free groups, and their Platelet (PLT), CD4⁺/CD8⁺, Cystatin C (CysC), pre- and post-operative serum creatinine (Scr) were determinated.

Results

Among the 127 patients (median age 38.7 ± 5.4 y, range 18–65 y), 61 patients (48%) suffered from hospital acquired infection during the first three months after kidney transplantation. Furthermore, the hypertension complications were found to be associated with the postoperative patient status (P < 0.01). The prognosis of patients was not related to Platelet (PLT) (P = 0.27), CD4⁺/CD8⁺ (P = 0.38) and Cystatin C (CysC) (P = 0.35). However, both preoperative Scr and postoperative Scr were significant higher in patients who suffered from postoperative infection than that in event free patients (P = 0.002 and P = 0.007, respectively).

Conclusions

It was found that the hypertension complications could aggravate patient status after renal transplant. Furthermore, because both preoperative Scr and postoperative Scr can be used to predict the hospital acquired infection of kidney transplant patients, the duration of taking prophylactic antibiotics for patients with higher levels of pre- and post-operative Scr should be properly extended.