Tissue Glue Adhesion for Plaque Radiotherapy of Uveal Melanoma in Humans: An Initial Experience.

IF 0.9 Q4 OPHTHALMOLOGY
Ocular Oncology and Pathology Pub Date : 2023-08-01 Epub Date: 2023-02-09 DOI:10.1159/000529382
Kushal U Agrawal, Nicholas E Kalafatis, Konica Singla, Sara E Lally, Carol L Shields
{"title":"Tissue Glue Adhesion for Plaque Radiotherapy of Uveal Melanoma in Humans: An Initial Experience.","authors":"Kushal U Agrawal, Nicholas E Kalafatis, Konica Singla, Sara E Lally, Carol L Shields","doi":"10.1159/000529382","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The aims of this study were to study use of tissue glue instead of conventional suturing and to secure I-125 plaque in human eyes with uveal melanoma.</p><p><strong>Methods: </strong>We studied 6 patients with choroidal melanoma undergoing plaque radiotherapy who were found to have thin sclera intraoperatively. Following tumor localization and plaque placement, tissue glue was applied over and around the plaque surface. The plaque was held securely in all cases. Conjunctivoplasty was performed with 7-0 vicryl sutures to ensure complete coverage and stability of the plaque. At the time of plaque removal, the tissue glue clot was in place with plaque secured. The clot and plaque were removed without difficulty.</p><p><strong>Results: </strong>In all 6 cases, the tissue glue secured the plaque in place for the required radiation duration (mean 117.6 h (hrs), median 103.1 h, range 101.6-162.5 h) delivering a tumor apex dose (mean 63.6 cGy/h, median 69.6 cGy/h, range 44.7-70.5 cGy/h). At the time of plaque removal, the plaque was in the designated position without displacement in all cases. There were no toxicities from the tissue glue.</p><p><strong>Conclusions: </strong>Tissue glue can serve as an alternative for fixation of plaque radiotherapy to the sclera without the need for suturing. This technique might be useful in eyes with thin sclera.</p>","PeriodicalId":19434,"journal":{"name":"Ocular Oncology and Pathology","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821786/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Oncology and Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000529382","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/9 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: The aims of this study were to study use of tissue glue instead of conventional suturing and to secure I-125 plaque in human eyes with uveal melanoma.

Methods: We studied 6 patients with choroidal melanoma undergoing plaque radiotherapy who were found to have thin sclera intraoperatively. Following tumor localization and plaque placement, tissue glue was applied over and around the plaque surface. The plaque was held securely in all cases. Conjunctivoplasty was performed with 7-0 vicryl sutures to ensure complete coverage and stability of the plaque. At the time of plaque removal, the tissue glue clot was in place with plaque secured. The clot and plaque were removed without difficulty.

Results: In all 6 cases, the tissue glue secured the plaque in place for the required radiation duration (mean 117.6 h (hrs), median 103.1 h, range 101.6-162.5 h) delivering a tumor apex dose (mean 63.6 cGy/h, median 69.6 cGy/h, range 44.7-70.5 cGy/h). At the time of plaque removal, the plaque was in the designated position without displacement in all cases. There were no toxicities from the tissue glue.

Conclusions: Tissue glue can serve as an alternative for fixation of plaque radiotherapy to the sclera without the need for suturing. This technique might be useful in eyes with thin sclera.

用组织胶粘剂对人类葡萄膜黑色素瘤进行斑块放射治疗:初步经验。
目的:本研究的目的是研究如何使用组织胶代替传统的缝合方法,并在患有葡萄膜黑色素瘤的眼球中固定 I-125 斑块:我们对 6 名接受斑块放射治疗的脉络膜黑色素瘤患者进行了研究,术中发现他们的巩膜较薄。肿瘤定位和斑块放置后,在斑块表面和周围涂上组织胶。所有病例的斑块都被牢牢固定。用 7-0 vicryl 缝线进行结膜成形术,以确保斑块的完全覆盖和稳定性。去除斑块时,组织胶凝块与斑块固定在一起。结果:在所有 6 个病例中,组织胶固定斑块的时间都达到了所需的放射时间(平均 117.6 小时,中位数 103.1 小时,范围 101.6-162.5 小时),肿瘤顶点剂量(平均 63.6 cGy/h,中位数 69.6 cGy/h,范围 44.7-70.5 cGy/h)。切除斑块时,所有病例的斑块都在指定位置,没有移位。组织胶无毒性反应:组织胶可作为将斑块放射治疗固定在巩膜上的替代方法,而无需缝合。这项技术可能适用于巩膜较薄的眼睛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.40
自引率
0.00%
发文量
20
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信