Efficacy of the Intrauterine Infusion of Platelet-Rich Plasma on Pregnancy Outcomes in Patients With Repeated Implantation Failure: A Randomized Control Trial
L. Safdarian, A. Aleyasin, M. Aghahoseini, Parvaneh Lak, Sedigheh Hoseini Mosa, F. Sarvi, A. Mahdavi, Aida Najafian, Parvin Falahi, S. Khazaei
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引用次数: 7
Abstract
Objectives: The aim of the present study was to evaluate the effect of the intrauterine administration of platelet-rich plasma (PRP) before embryo transfer (ET) on pregnancy outcomes in women with repeated implantation failure (RIF). Materials and Methods: This randomized controlled trial included 120 RIF women who were candidates for frozen-thawed ET. In the PRP group (n=60), the intrauterine infusion of 0.5 mL PRP was performed 48 hours before ET, and the control group (n=60) underwent ET without intrauterine administration. Results: The implantation rate (28% vs. 11.9%, P<0.001), clinical pregnancy (51.6% vs. 26.6%, P=0.005), and live birth rate (58.3% vs. 28.3%, P=0.001) in PRP group were significantly higher compared to the control group. Based on the results, there was no significant difference with regard to miscarriage (12.5% vs. 12.9%, P=0.97) and multiple pregnancy rate (0.133% vs. 0.05%, P=0.11) between the two groups. Finally, preterm delivery was significantly higher in the PRP group (P<0.001). Conclusions: According to this study, the result revealed that PRP is effective in the improvement of pregnancy outcomes in RIF patients. Further studies are needed to identify the group of patients who would benefit from this intervention.
目的:本研究的目的是评估胚胎移植(ET)前宫内给予富血小板血浆(PRP)对反复着床失败(RIF)妇女妊娠结局的影响。材料与方法:本随机对照试验纳入120例冷冻解冻ET候选者的RIF妇女。PRP组(n=60)在ET前48小时宫内输注0.5 mL PRP,对照组(n=60)行ET,不宫内给药。结果:PRP组着床率(28% vs. 11.9%, P<0.001)、临床妊娠率(51.6% vs. 26.6%, P=0.005)、活产率(58.3% vs. 28.3%, P=0.001)显著高于对照组。结果显示,两组流产率(12.5%比12.9%,P=0.97)、多胎妊娠率(0.133%比0.05%,P=0.11)差异无统计学意义。最后,PRP组的早产率显著高于对照组(P<0.001)。结论:本研究结果显示PRP可有效改善RIF患者妊娠结局。需要进一步的研究来确定从这种干预中受益的患者群体。
期刊介绍:
All kind of knowledge contributing to the development of science by its content, value, level and originality will be covered by IJWHR. Problems of public health and their solutions are at the head of the windows opening us to the world. The "International Journal of Women''s Health and Reproduction Sciences” is a modern forum for scientific communication, covering all aspects women health and reproduction sciences, in basic and clinical sciences, mainly including: -Medical Education in Women Health and Reproduction Sciences -Cardiology in Women Health-Related Reproductive Problems -Sports Medicine in Women Health and Reproduction Sciences -Psychiatry in Women Health-Related Reproductive Problems -Antioxidant Therapy in Reproduction Medicine Sciences -Nutrition in Women Health and Reproduction Sciences -Defense Androgen and Estrogen -Fertility and Infertility -Urogynecology -Endometriosis -Endocrinology -Breast Cancer -Menopause -Puberty -Eroticism -Pregnancy -Preterm Birth -Vaginal Diseases -Sex-Based Biology -Surgical Procedures -Nursing in Pregnancy -Obstetrics/Gynecology -Polycystic Ovary Syndrome -Hyperandrogenism in Females -Menstrual Syndrome and Complications -Oncology of Female Reproductive Organs -Traditional Medicine in Women Reproductive Health -Ultrasound in Women Health Reproduction sciences -Stem Cell Research In Women Reproduction Sciences -Complementary Medicine in Women Reproductive Health -Female Sexual Dysfunction: Pathophysiology & Treatment