Aqueous humor and iris mechanics in synechial closure in primary angle-closure glaucoma

Abstract

Primary angle-closure glaucoma features a narrow anterior chamber angle in which the anteriorly positioned iris blocks aqueous humor outflow through the trabecular meshwork, subsequently increasing the intraocular pressure. A mathematical model is used to investigate the aqueous humor-iris interaction in synechial angle closure. The model predicted increased intraocular pressure as the anterior chamber angle decreased and a plateau iris configuration in synechial angle closure - consistent with clinical observations.