Suppressive Effects of Polysaccharide Produced by Bacillus circulans on Chemical Mutagens-Induced SOS Response in Salmonella typhimurium

Abstract

The suppressing effects of polysaccharide produced by Bacillus circulans on the SOS response of Salmonella typhimurium TA 1535/pSK1002 induced by AF-2, MNNG, 4NQO, Trp-P-2, IQ and MeIQx were compared with those of commercial polysaccharides to find a new physiological value as an additive to processed foodstuffs. The native polysaccharide produced by B. circulans strongly suppressed SOS response induced by IQ and MeIQx, and the suppression was increased with increasing polysaccharide concentration. Xanthan gum, which is an acidic polysaccharide produced by Xanthomonas campestris, and carboxymethyl cellulose (CMC) did not suppress SOS response induced by mutagens.