Association of Cell-Free Fetal DNA at 11-17 Weeks of Pregnancy and the Outcome of Pregnancy

IF 0.8 Q4 REPRODUCTIVE BIOLOGY
S. Borna, Azam Tarafdari, Hedyeh Khenar, Amirhossein Zabolian, Ava Ajir, Shima Mohammadi, A. Hosseini
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Abstract

Objectives: This study aimed to evaluate the association between cell-free fetal DNA (cffDNA) levels in the first and second trimesters and adverse pregnancy outcomes. Materials and Methods: This was a retrospective cohort study including all women who had cffDNA measurement as a primary or secondary screening test for chromosomal abnormalities in a screening laboratory in Iran. Results: Totally, 481 out of 634 pregnant women (75.9%) did not develop any pregnancy complications. On the other hand, 55 pregnancies (8.7%) led to preterm delivery. Based on the results, 33 pregnant women (5.2%) gave birth to intrauterine growth restriction (IUGR) babies and 16 pregnant women (2.52%) developed preeclampsia (PE). Moreover, 15 women developed gestational diabetes. Further, 11 pregnancies resulted in abortion and 6 pregnancies led to fetal death. There was a positive association between the duration of pregnancies and the weight of the babies at birth (r=0.362, P=0.000). There was a statistically significant association between the increase in cffDNA level and trisomy (P=0.000) and the decrease in cffDNA level and the incidence of PE (P=0.019). Conclusions: The reduction of plasma cffDNA level in pregnancies led to PE and the elevation of cffDNA results in fetal trisomy. However, further studies will be required to confirm these findings.
妊娠11-17周无细胞胎儿DNA与妊娠结局的关系
目的:本研究旨在评估妊娠早期和中期无细胞胎儿DNA (cffDNA)水平与不良妊娠结局之间的关系。材料和方法:这是一项回顾性队列研究,包括所有在伊朗筛查实验室进行cffDNA检测作为染色体异常的主要或次要筛查试验的妇女。结果:634例孕妇中481例(75.9%)未发生妊娠并发症。另一方面,55例妊娠(8.7%)导致早产。结果显示,宫内生长受限(IUGR)患儿33例(5.2%),发生子痫前期(PE) 16例(2.52%)。此外,15名妇女患上了妊娠糖尿病。此外,11例妊娠导致流产,6例妊娠导致胎儿死亡。妊娠期与婴儿出生体重呈正相关(r=0.362, P=0.000)。cffDNA水平升高与三体病相关(P=0.000), cffDNA水平降低与PE发生率相关(P=0.019),有统计学意义。结论:妊娠期血浆cffDNA水平降低导致PE, cffDNA水平升高导致胎儿三体。然而,需要进一步的研究来证实这些发现。
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来源期刊
CiteScore
1.60
自引率
14.30%
发文量
8
期刊介绍: All kind of knowledge contributing to the development of science by its content, value, level and originality will be covered by IJWHR. Problems of public health and their solutions are at the head of the windows opening us to the world. The "International Journal of Women''s Health and Reproduction Sciences” is a modern forum for scientific communication, covering all aspects women health and reproduction sciences, in basic and clinical sciences, mainly including: -Medical Education in Women Health and Reproduction Sciences -Cardiology in Women Health-Related Reproductive Problems -Sports Medicine in Women Health and Reproduction Sciences -Psychiatry in Women Health-Related Reproductive Problems -Antioxidant Therapy in Reproduction Medicine Sciences -Nutrition in Women Health and Reproduction Sciences -Defense Androgen and Estrogen -Fertility and Infertility -Urogynecology -Endometriosis -Endocrinology -Breast Cancer -Menopause -Puberty -Eroticism -Pregnancy -Preterm Birth -Vaginal Diseases -Sex-Based Biology -Surgical Procedures -Nursing in Pregnancy -Obstetrics/Gynecology -Polycystic Ovary Syndrome -Hyperandrogenism in Females -Menstrual Syndrome and Complications -Oncology of Female Reproductive Organs -Traditional Medicine in Women Reproductive Health -Ultrasound in Women Health Reproduction sciences -Stem Cell Research In Women Reproduction Sciences -Complementary Medicine in Women Reproductive Health -Female Sexual Dysfunction: Pathophysiology & Treatment
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