具有对称结构手性氨基酚化合物的合成 Synthesis of Symmetric Chiral Aminophenol Compounds

Abstract

分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.