A new Spectrophotometric Approach for Determination of Meropenem in Pharmaceutical Formulation

Abstract

A new, sensitive spectrophotometric determination of meropenem (MRP) the broad-spectrum carbapenem antibiotic has been suggested using p-aminobiphenyl amine reagent and periodate in 6M HCl media to form one to one blue color complex with maximum peak at 716nm.The reaction is carried out at room temperature, Beer’s law is followed from 10 to 125 µg/mL, the molar absorptivity is 1265.22 L/mole.cm., LOD, LOQ are 0.0202, and 0.0673 ppm respectively, the method has been applied for estimation of MRP in vials with high accuracy (error % 0.0106) and good precision (RSD % ±0.0319)