Antiphospholipid Antibodies – a tool for the screening of repeated spontaneous abortion

Abstract

Objective:- To evaluate the biomedical and clinical significance of antiphospholipid antibodies in women with repeated spontaneous abortion. Place & Duration:- Mohi-u-Din Islamci Medical College & DHQ Hospital, Mirpur, AJ & K, from March to December 2013. Methodology:- 50 subjects with history of three spontaneous abortions in their first trimester of pregnancy were included in this study & fifty women of corresponding age, with one, more alive babies having no record of any first three months spontaneous abortion were taken as controls. Coagulation tests, platelet count, prothrombin time and activated partial thromboplastin time were done by standards methods. Antiphospholipid Antibodies were estimated by ELISA method using specific kits. Results:- Mean serum Antiphospholipid Antibodies level was 7.10 + 3.47 in patients and 6.30 + 2.02 in controls. The difference in serum level of two groups was significant. Mean platelet count, mean prothrombin time & activated partial thromboplastin time revealed no significant difference between patients and controls. Conclusion:- It is concluded that there is a strong association of antiphospholipid antibodies in the patients having recurrent spontaneous abortions so there is a strong need of including this test in the primary screening of such disease in the pregnant women who have history of previous repeated spontaneous abortion.