Supplementation of Corosolic Acid Prevents the Development of Neuropathic Pain in Streptozotocin Induced Diabetic Rats

A. Upaganlawar, C. Upasani
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引用次数: 1

Abstract

The present study was design to screen the neuroprotective and antioxidant activity of corosolic acid in painful diabetic neuropathy (DN).  Diabetes was induced in rats by single dose of STZ (60mg/kg, i.p). Diabetic rats were tested week for the development of pain, at 6th week the rats developed significant neuropathic pain. They were divided into different groups and treated with Corosolic acid (2 and 4 mg/kg, p.o) for further two weeks. Pain was assessed in the diabetic rats by mechano-tactil allodynia, mechanical hyperalgesia and cold allodynia. At the end of treatment period rats were scarified and biochemical changes such as plasma glucose level, endogenous antioxidants (Lipid peroxidation, reduced glutathione, superoxide dismutase and catalase) in sciatic nerve were evaluated. Further Na+/K+ ATPase and nitric oxide content was also evaluated. Treatment with corosolic acid for two weeks restored the altered body weight and elevated blood sugar level. Further corosolic acid showed dose dependent reduction in pain in neuropathic animals. The level of endogenous antioxidants enzymes, Na+/K+ ATPase and nitric oxide were significantly prevented. In conclusion. The result of the present study suggests the antidiabetic, antioxidant and neuroprotectieve property of corosolic acid in diabetic rats with neuropathic pain.
补充科罗索酸可预防链脲佐菌素诱导的糖尿病大鼠神经性疼痛的发生
本研究旨在筛选柯罗果酸对疼痛性糖尿病神经病变(DN)的神经保护和抗氧化活性。STZ单剂量(60mg/kg, ig)诱导大鼠糖尿病。第6周,糖尿病大鼠出现明显的神经性疼痛。将它们分成不同的组,分别给予柯罗果酸(2和4 mg/kg, p.o)再处理2周。采用机械触觉异常痛觉、机械痛觉过敏和冷异常痛觉评价糖尿病大鼠的疼痛。治疗期结束后,对大鼠进行切片,观察血浆葡萄糖水平、坐骨神经内源性抗氧化剂(脂质过氧化、还原性谷胱甘肽、超氧化物歧化酶和过氧化氢酶)的生化变化。进一步测定Na+/K+ atp酶和一氧化氮含量。用科罗索酸治疗两周后,体重恢复正常,血糖水平升高。进一步的科罗索酸显示出对神经性动物疼痛的剂量依赖性减轻。内源性抗氧化酶、Na+/K+ atp酶和一氧化氮水平显著降低。在结论。本研究结果提示柯罗果酸对糖尿病神经性疼痛大鼠具有抗糖尿病、抗氧化和神经保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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