Fundamentals of Diabetes Management.

B. Kulzer, J. Aberle, T. Haak, M. Kaltheuner, J. Kröger, R. Landgraf, M. Kellerer
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Abstract

Diabetes is a chronic disease that poses considerable challenges for people with diabetes in their daily therapy. In addition to drug therapy, the therapy behaviour of the person with diabetes plays a significant role in the prognosis of the disease. In diabetes therapy, it is therefore important to define therapy goals together with the person with diabetes, taking into account a multitude of biological, somatic, social and behavioural factors, and to support those affected as best as possible in implementing therapy goals into their personal living environment and their self-management. The most important superordinate therapy goals for diabetes are described in the evidence-based guidelines for type 1 and type 2 diabetes [1, 2], as well as in the Disease Management Program (DMP) requirements guideline (DMP-A-RL) [3]. ▪ Maintaining or improving the quality of life limited by diabetes: For people with diabetes, maintaining the quality of life is the most important goal of diabetes therapy [4]. This means remaining as physically and psychologically healthy as possible despite and with diabetes, being able to realise one’s own life goals and being socially integrated – without being limited in areas of life that are important for people, such as family/relationship, job, interests, leisure time, etc. Study results show relatively consistently that these goals, which are important for people with diabetes, have not yet been achieved worldwide [5, 6]. ▪ Preventing symptoms of the disease: Elevated, decreased or even highly-fluctuating glucose levels (increased glucose variability) can lead to symptoms such as an increased urge to urinate (polyuria), a strong feeling of thirst (polydipsia), fatigue, weakness and tiredness. Symptoms that should be avoided during therapy also include dry or itchy skin, neuropathic symptoms and fluctuations in lens refractive power due to osmotic effects of increased glucose levels. ▪ Preventing acute complications: It is important to prevent side effects of antihyperglycaemic therapy, in particular hypoglycaemia – especially severe hypoglycaemia in which the affected person is dependent on external help (e. g., by relatives or medical staff). As well, it is important to prevent severe hyperglycaemic metabolic derailments (e. g., diabetic ketoacidosis) because of the associated burdens and dangers for the person with diabetes, as well as the associated health risks, which can be lethal in some cases. Fundamentals of Diabetes Management
糖尿病管理基础。
糖尿病是一种慢性疾病,对糖尿病患者的日常治疗提出了相当大的挑战。除药物治疗外,糖尿病患者的治疗行为对疾病的预后也起着重要作用。因此,在糖尿病治疗中,重要的是与糖尿病患者一起确定治疗目标,考虑到多种生物、躯体、社会和行为因素,并尽可能地支持那些受影响的人在他们的个人生活环境和自我管理中实施治疗目标。1型和2型糖尿病的循证指南[1,2]以及疾病管理计划(DMP)要求指南(DMP- a - rl)[3]中描述了糖尿病最重要的上级治疗目标。▪维持或改善受糖尿病限制的生活质量:对于糖尿病患者来说,维持生活质量是糖尿病治疗最重要的目标[4]。这意味着即使患有糖尿病,也要尽可能保持身体和心理健康,能够实现自己的生活目标,融入社会——不受家庭/关系、工作、兴趣、休闲时间等对人们重要的生活领域的限制。研究结果相对一致地表明,这些对糖尿病患者很重要的目标尚未在全球范围内实现[5,6]。▪预防疾病症状:血糖水平升高、降低甚至剧烈波动(血糖变异性增加)可导致尿频增加(多尿)、强烈口渴感(渴渴)、疲劳、虚弱和疲倦等症状。治疗期间应避免的症状还包括皮肤干燥或发痒、神经病变症状以及由于葡萄糖水平升高的渗透效应引起的晶状体屈光度波动。▪预防急性并发症:重要的是要预防抗高血糖治疗的副作用,特别是低血糖——特别是严重低血糖,患者依赖外部帮助(如亲属或医务人员)。此外,预防严重的高血糖代谢脱轨(如糖尿病酮症酸中毒)也很重要,因为这会给糖尿病患者带来相关的负担和危险,以及相关的健康风险,在某些情况下可能是致命的。糖尿病管理基础
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