Pasqua Dipasquale , Adele Romano , Silvia Cianci, Laura Righetti, Silvana Gaetani
{"title":"Oleoylethanolamide: a new player in energy metabolism control. Role in food intake","authors":"Pasqua Dipasquale , Adele Romano , Silvia Cianci, Laura Righetti, Silvana Gaetani","doi":"10.1016/j.ddmec.2011.01.004","DOIUrl":null,"url":null,"abstract":"<div><p>Oleoylethanolamide<span> (OEA) is a lipid amide produced by enterocytes upon the absorption of dietary fat and participates in the induction of satiety. Through indirect pathways, probably depending on the local activation of peroxisome-proliferator-activated receptor-alpha and involving afferent vagus nerve fibers, OEA signal is transmitted to the brain-stem and the hypothalamus, where it stimulates the release of oxytocin from magnocellular neurons.</span></p><p>OEA mechanism might, thus, provide a novel target for the design of therapies controlling appetite.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 3","pages":"Pages e169-e174"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.01.004","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676511000058","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16
Abstract
Oleoylethanolamide (OEA) is a lipid amide produced by enterocytes upon the absorption of dietary fat and participates in the induction of satiety. Through indirect pathways, probably depending on the local activation of peroxisome-proliferator-activated receptor-alpha and involving afferent vagus nerve fibers, OEA signal is transmitted to the brain-stem and the hypothalamus, where it stimulates the release of oxytocin from magnocellular neurons.
OEA mechanism might, thus, provide a novel target for the design of therapies controlling appetite.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
