On the possibility of using cationic surfactants to impart antimicrobial properties to textile materials

Anastasia S. Zvereva, Sergey V. Andreev, A. Serov, S. Zverev, Vyacheslav A. Novikov, Alexandra D. Kritskaya, V. Vinokurov, K. A. Sakharov
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Abstract

The COVID-19 pandemic has demonstrated the need for improved measures to prevent infectious diseases. Combating pathogens once they have been released into the environment is complicated by their widespread distribution. It is necessary to prevent the contamination of environmental objects. One possible way to do this is to create materials that have antimicrobial action without exposure to disinfectants and thus begin to have an antimicrobial effect on microorganisms immediately upon contact. Textile materials are widely used in medical organizations and are one of the factors of pathogenic microflora spreading. In this work, the possibility of using substances from the group of cationic surfactants to impart antimicrobial properties to textile materials was considered. Substances from different classes were used – tertiary amines, quaternary ammonium compounds, polymeric guanidine derivatives. The substances were applied from aqueous solutions using a laboratory analogue of a drying and a shirring machine. An acrylate binder with thermal initiation of polymerization was used to fix the active substances to the tissues. The content of the active substances in the tissues after application was determined by high-performance liquid chromatography. Antimicrobial activity of the obtained materials was checked by the agar plate method and the area of the growth retardation zone was estimated. Tissues containing N,N-bis(3-aminopropyl)dodecylamine showed the highest activity, tissues with poly (2-hydroxypropyl dimethylammonium) chloride the lowest. Keywords: antimicrobial materials, antimicrobial textile, HAI, cationic surfactants.
利用阳离子表面活性剂赋予纺织材料抗菌性能的可能性
COVID-19大流行表明,有必要改进预防传染病的措施。一旦病原体被释放到环境中,由于它们的广泛分布,与它们作斗争变得复杂。要防止对环境物体的污染。一种可能的方法是制造出无需接触消毒剂就具有抗菌作用的材料,从而在接触微生物后立即开始对微生物产生抗菌作用。纺织材料广泛应用于医疗机构,是病原菌群传播的因素之一。在这项工作中,考虑了使用阳离子表面活性剂基团中的物质赋予纺织材料抗菌性能的可能性。使用了不同类别的物质-叔胺,季铵化合物,聚合胍衍生物。这些物质是用实验室模拟的干燥和起皱机从水溶液中施用的。采用热引发聚合的丙烯酸酯粘合剂将活性物质固定在组织上。采用高效液相色谱法测定涂敷后组织中活性物质的含量。用琼脂平板法测定所得材料的抑菌活性,并估计生长迟缓区面积。含N,N-二(3-氨基丙基)十二烷基胺的组织活性最高,含聚(2-羟丙基二甲基氯化铵)的组织活性最低。关键词:抗菌材料,抗菌纺织品,HAI,阳离子表面活性剂
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