Coagulation Parameters among Women with Obstetric Complications in Specialist Hospital Sokoto, Nigeria

Onuigwe Festus Uchechukwu, Khadija Bello Tudu, Erhabor Osaro, Buhari Hauwa Ali, B. A. Ibrahim, Amilo Grace Ifechukwudebelu, Ibeh Nancy Chitogu
{"title":"Coagulation Parameters among Women with Obstetric Complications in Specialist Hospital Sokoto, Nigeria","authors":"Onuigwe Festus Uchechukwu, Khadija Bello Tudu, Erhabor Osaro, Buhari Hauwa Ali, B. A. Ibrahim, Amilo Grace Ifechukwudebelu, Ibeh Nancy Chitogu","doi":"10.9734/ibrr/2020/v11i230127","DOIUrl":null,"url":null,"abstract":"Background and Aim: Obstetric complications are part of the leading causes of maternal mortality worldwide. This study was carried out to investigate the effect of   complications on the Prothrombin time (PT), activated partial thromboplastin time (APTT), and platelet count (PLC). Women with obstetric complications were recruited as subjects). Pregnant women without complications were included as controls. \nStudy Design: This is a case-control study. \nPlace and Duration of Study: The study took place in Obstetrics and Gynaecology Department of Specialist Hospital Sokoto and the duration was six months. \nMethodology: Pregnant women aged 18–41 years (mean age 29.5 years) were recruited for the study. The determination of PT and APTT was done by manual methods using commercially prepared Agappe reagent kits, whereas PLC was done by manual methods using a haemocytometer (Improved Neubauer counting chamber). Data were analyzed using SPSS version 23. \nResults: The results of PT and APTT were significantly higher among women with obstetric complications (14.26±0.23 seconds and 31.32±0.70 second) compared to normal pregnant women (13.00 ± 0.13 seconds and 29.66±0.33) (P<0.05). The PLC was significantly lower among women with obstetric complications compared to women without obstetric complications (P< 0.05).Obstetric complications in subject show a significant association when compared with PT and APTT (P< 0.05). The age group of subjects shows a significant association when compared with APTT (P< 0.05). \nConclusion: Findings from this study have shown that obstetric complications causes decrease in platelet count and prolongation in PT and APTT. There is need to assess the PT, APTT and Platelet count routinely for pregnant women to improve the ante-natal care in Specialist Hospital Sokoto.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Blood Research & Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/ibrr/2020/v11i230127","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background and Aim: Obstetric complications are part of the leading causes of maternal mortality worldwide. This study was carried out to investigate the effect of   complications on the Prothrombin time (PT), activated partial thromboplastin time (APTT), and platelet count (PLC). Women with obstetric complications were recruited as subjects). Pregnant women without complications were included as controls. Study Design: This is a case-control study. Place and Duration of Study: The study took place in Obstetrics and Gynaecology Department of Specialist Hospital Sokoto and the duration was six months. Methodology: Pregnant women aged 18–41 years (mean age 29.5 years) were recruited for the study. The determination of PT and APTT was done by manual methods using commercially prepared Agappe reagent kits, whereas PLC was done by manual methods using a haemocytometer (Improved Neubauer counting chamber). Data were analyzed using SPSS version 23. Results: The results of PT and APTT were significantly higher among women with obstetric complications (14.26±0.23 seconds and 31.32±0.70 second) compared to normal pregnant women (13.00 ± 0.13 seconds and 29.66±0.33) (P<0.05). The PLC was significantly lower among women with obstetric complications compared to women without obstetric complications (P< 0.05).Obstetric complications in subject show a significant association when compared with PT and APTT (P< 0.05). The age group of subjects shows a significant association when compared with APTT (P< 0.05). Conclusion: Findings from this study have shown that obstetric complications causes decrease in platelet count and prolongation in PT and APTT. There is need to assess the PT, APTT and Platelet count routinely for pregnant women to improve the ante-natal care in Specialist Hospital Sokoto.
尼日利亚索科托专科医院产科并发症妇女的凝血参数
背景和目的:产科并发症是全世界孕产妇死亡的主要原因之一。本研究旨在探讨并发症对凝血酶原时间(PT)、活化部分凝血活素时间(APTT)和血小板计数(PLC)的影响。有产科并发症的妇女被招募为研究对象)。无并发症的孕妇作为对照。研究设计:这是一项病例对照研究。研究地点和持续时间:研究在索科托专科医院妇产科进行,持续时间为6个月。方法:研究招募年龄在18-41岁(平均年龄29.5岁)的孕妇。PT和APTT的测定采用人工方法,使用商业制备的Agappe试剂盒,而PLC的测定采用人工方法,使用血细胞计(改进的Neubauer计数室)。数据分析采用SPSS version 23。结果:产科并发症组PT、APTT评分分别为14.26±0.23秒和31.32±0.70秒,显著高于正常妊娠组(13.00±0.13秒和29.66±0.33秒),差异有统计学意义(P<0.05)。有产科并发症妇女的PLC明显低于无产科并发症妇女(P< 0.05)。与PT和APTT相比,受试者的产科并发症有显著相关性(P< 0.05)。与APTT比较,各年龄组间存在显著相关性(P< 0.05)。结论:本研究结果表明,产科并发症导致血小板计数下降,延长PT和APTT时间。有必要对孕妇的PT、APTT和血小板计数进行常规评估,以改善索科托专科医院的产前护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信