AN EXPERIMENTAL STUDY OF PROTECTIVE AND THERAPEUTIC EFFECTS OF PROBIOTICS ON INFECTION BY TOXOPLASMA GONDII

Abstract

One of the most significant opportunistic parasites causing serious infections in humans is Toxoplasma gondii ( T. gondii ). Lack of maximally effective therapeutic drugs for chronic tox-oplasmosis necessitates the search for a reliable and safe toxoplasmosis therapy. This study evaluated, compared, and contrasts the curative and preventative effects of probiotics on mice infected with the ME49 strain of T. gondii , as well as to contrast these effects with those of spiramycin. Probiotic effects were assessed using research in parasitology, histopathology, immunology, and immunohistochemistry. The results showed that probiotics were more helpful when administered as a preventative measure than when provided as a treatment for toxo-plasmosis. Toxoplasma gondii cyst counts in the brain were successfully decreased by probiotics. The inflammation in the heart, eyes, and brain also lessened as a result. Besides, it led to a rise in interleukin-10 (IL-10) and a fall in Interferon-gamma (IFN-brain, heart, and eyes, it also reduced the expression of cluster of differentiation 3 (CD3) and Caspase3. It was less effective than spiramycin, nevertheless, as a therapy.