Candida species as potential nosocomial pathogens – A review

V. Jahagirdar, M. Davane, Shrey C. Aradye, B. Nagoba
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引用次数: 24

Abstract

The frequency of nosocomial fungal infections is being increased because of the advent of newer diagnostic and therapeutic techniques. Among various fungal pathogens, Candida spp. are the cause of substantial morbidity and mortality in hospitalized patients, especially among critically ill hospitalized patients. The frequency of non-ablicans spp. of Candida (NAC) causing nosocomial infections is increasing. The Candida infections are usually endogenous, however, the exogenous infections may also occur. The important predisposing factors leading to nosocomial candidiasis include treatment with broad spectrum antibiotics, immunosuppression, malignancy, surgical intervention, diabetes and prolonged hospitalization. Virulence factors like adherence to biotic and abiotic substances and production of hydrolytic enzymes play important role. Also the biofilm forming ability makes it more noxious. Nosocomial Candida infections are difficult to diagnose clinically and refractory to therapy. Therefore, rapid and accurate laboratory diagnosis is very important to provide appropriate antifungal treatment. This review is structured to know the key factors responsible for emergence of Candida spp. as important nosocomial pathogens. The available data suggests that the nosocomial infections caused by Candida spp. should be dealt through awareness and constant vigilance.
念珠菌作为潜在的医院病原菌——综述
由于新的诊断和治疗技术的出现,医院真菌感染的频率正在增加。在各种真菌病原体中,念珠菌是导致住院患者,特别是危重住院患者大量发病和死亡的原因。念珠菌(NAC)引起医院感染的频率呈上升趋势。念珠菌感染通常为内源性感染,但也可能发生外源性感染。导致院内念珠菌病的重要易感因素包括广谱抗生素治疗、免疫抑制、恶性肿瘤、手术干预、糖尿病和长期住院。对生物和非生物物质的粘附以及水解酶的产生等毒力因素起着重要作用。此外,生物膜的形成能力使其更具毒性。院内念珠菌感染临床诊断困难,治疗难。因此,快速准确的实验室诊断对于提供适当的抗真菌治疗非常重要。本综述旨在了解导致念珠菌属作为重要的医院病原菌出现的关键因素。现有资料表明,念珠菌引起的医院感染应通过意识和持续警惕来处理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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