Applications of headspace solid-phase microextraction in human biological matrix analysis

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Reviews in Analytical Chemistry Pub Date : 2022-01-01 DOI:10.1515/revac-2022-0042

X. Ji

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引用次数: 1

Abstract

Abstract The inherent complexity of the human biological matrix and its importance in modern medical diagnosis and medical research promote the development of modern analytical technology. Solid-phase microextraction technology has been widely used in the treatment and analysis of different complex biological matrices due to its smaller sample size, simpler sample preparation and setting, and lower consumption of harmful chemicals. This review provides updated information on headspace solid-phase microextraction combined with gas chromatography technique applications, focusing on the analysis of volatile and semivolatile compounds in human biological matrices. The application of headspace solid-phase microextraction combined with gas chromatography techniques in human biological matrix analysis is mainly summarized into three aspects, namely, to discover biomarkers, to investigate volatile metabolomics, and to explore the effect of the external environment on volatile metabolomics of the human biological matrix. In addition, the frequently used statistical analytical methods are summarized, and the application prospect of solid-phase microextraction in the analysis of human biological matrices is proposed.

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顶空固相微萃取在人体生物基质分析中的应用

人体生物基质的内在复杂性及其在现代医学诊断和医学研究中的重要性推动了现代分析技术的发展。固相微萃取技术因其样品体积小、样品制备和设置简单、有害化学物质消耗少等优点，已广泛应用于各种复杂生物基质的处理和分析。本文综述了顶空固相微萃取结合气相色谱技术应用的最新进展，重点介绍了人体生物基质中挥发性和半挥发性化合物的分析。顶空固相微萃取结合气相色谱技术在人体生物基质分析中的应用主要归纳为三个方面，即发现生物标志物、研究挥发性代谢组学、探索外部环境对人体生物基质挥发性代谢组学的影响。此外，总结了常用的统计分析方法，并提出了固相微萃取在人体生物基质分析中的应用前景。

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来源期刊

Reviews in Analytical Chemistry 化学-分析化学

CiteScore

7.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.