Impairments in intrinsic functional networks in type 2 diabetes: A meta-analysis of resting-state functional connectivity

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI:10.1016/j.yfrne.2022.100992

Jinli Meng , Jing Liu , Hailong Li , Yingxue Gao , Lingxiao Cao , Yuanyuan He , Yongyue Guo , Li Feng , Xin Hu , Hengyan Li , Chenghui Zhang , Wanlin He , Yunhong Wu , Xiaoqi Huang

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引用次数: 3

Abstract

Type 2 diabetes mellitus (T2DM) is associated with abnormal communication among large-scale brain networks, revealed by resting-state functional connectivity (rsFC), with inconsistent results between studies. We performed a meta-analysis of seed-based rsFC studies to identify consistent network connectivity alterations. Thirty-three datasets from 30 studies (1014 T2DM patients and 902 healthy controls [HC]) were included. Seed coordinates and between-group effects were extracted, and the seeds were divided into networks based on their location. Compared to HC, T2DM patients showed hyperconnectivity and hypoconnectivity within the DMN, DMN hypoconnectivity with the affective network (AN), ventral attention network (VAN) and frontal parietal network, and DMN hyperconnectivity with the VAN and visual network. T2DM patients also showed AN hypoconnectivity with the somatomotor network and hyperconnectivity with the VAN. T2DM illness durations negatively correlated with within-DMN rsFC. These DMN-centered impairments in large-scale brain networks in T2DM patients may help to explain the cognitive deficits associated with T2DM.

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2型糖尿病内在功能网络的损伤:静息状态功能连接的荟萃分析

静息状态功能连接(rsFC)显示，2型糖尿病(T2DM)与大尺度脑网络之间的异常通信有关，但研究结果不一致。我们对基于种子的rsFC研究进行了meta分析，以确定一致的网络连接改变。纳入了来自30项研究的33个数据集(1014名T2DM患者和902名健康对照[HC])。提取种子坐标和组间效应，根据种子所在位置将种子划分为网络。与HC相比，T2DM患者表现为DMN内部的超连通性和低连通性，DMN与情感网络(AN)、腹侧注意网络(VAN)和额顶叶网络的低连通性，DMN与VAN和视觉网络的超连通性。T2DM患者还表现出AN与躯体运动网络的低连通性和与VAN的高连通性。T2DM病程与dmn内rsFC呈负相关。T2DM患者大规模脑网络中以dmn为中心的损伤可能有助于解释与T2DM相关的认知缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.