Plasma Levels of CA125, CEA, AFP and Cortisol in Obesity

M. Akiibinu, Bob O. Soile, Ajibola M. U. Amzat, Olatunji T. Kolawole
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引用次数: 1

Abstract

Background: In obesity, modulation of metabolic pathways plays critical roles in the pathogenesis of many diseases. The present study therefore tried to link obesity, metabolic stress and tumor by evaluating the levels of tumor markers and cortisol (a stress-induced hormone) in obesity. Materials: Thirty-three obese (18 males, 15 females, body mass index=34 ± 3.8 Kg/m2) and 37 apparently nonobese (19 males, 18 females, body mass index=22 ± 1.4 Kg/m2) individuals (controls) volunteered to participate in this study. All participants were not on drugs (i.e. alcohol, cigarette or steroids) and were healthy adults without apparent medical problems. Every participant had his/her body weight and height taken, and the body mass index (BMI) calculated before inclusion in the study. Plasma levels of carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), alpha fetoprotein (AFP) and cortisol were determined in these subjects using enzyme linked immunosorbent assay methods. Results: In the obese subjects, plasma values of CA125 and cortisol increased significantly (p 0.05) changes in the obese when compared with controls Conclusion: Metabolic changes could account for the increased rate of synthesis of cortisol and CA125 in obesity.
肥胖症患者血浆CA125、CEA、AFP和皮质醇水平的变化
背景:在肥胖中,代谢途径的调节在许多疾病的发病机制中起着关键作用。因此,目前的研究试图通过评估肥胖中肿瘤标志物和皮质醇(一种应激诱导激素)的水平来将肥胖、代谢应激和肿瘤联系起来。材料:33例肥胖个体(男性18例,女性15例,体重指数=34±3.8 Kg/m2)和37例明显非肥胖个体(男性19例,女性18例,体重指数=22±1.4 Kg/m2)(对照组)自愿参加本研究。所有参与者都不吸毒(即酒精、香烟或类固醇),是没有明显医疗问题的健康成年人。在纳入研究之前,每个参与者都测量了他/她的体重和身高,并计算了身体质量指数(BMI)。采用酶联免疫吸附法测定血浆碳水化合物抗原125 (CA125)、癌胚抗原(CEA)、甲胎蛋白(AFP)和皮质醇水平。结果:肥胖者血浆CA125和皮质醇值较对照组显著升高(p < 0.05)。结论:代谢变化可能是肥胖者皮质醇和CA125合成速率升高的原因。
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