Maximum Standardized Uptake Value of F-18 FDG-PET Inversely Correlated with Immunoexpression of p16INK4a in Patients with Non-SmallCell Lung Cancer

The open pathology journal Pub Date : 2009-05-15 DOI:10.2174/1874375700903010033

I. Abdulkader, Á. Ruibal, J. Cameselle-Teijeiro, F. Gudé, J. J. Christensen, L. León, P. Arce-Calisaya, A. Sánchez-Salmón, J. Forteza

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引用次数: 1

Abstract

We have studied the possible relationship between the immunohistochemical expression of p16 INK4a and the maximum standardized uptake value (SUV max) of F-18 fluorodeoxyglucose-positron emission tomography (F-18 FDG- PET) in 49 patients with non-small cell lung cancer (NSCLC). Immunohistochemical negativity of p16 INK4a was verified in 71.4 % of the patients, higher in squamous cell carcinomas than in adenocarcinomas (p: 0.033). The SUV max corre- lates with negativity for p16 INK4a (p: 0.042) and was higher (p: 0.024) in cases with p16 INK4a -negative (17.3 ± 8.3) than in cases with p16 INK4a -positive (12.7 ± 5.2). We can conclude that inactivation of the p16 INK4a gene is very frequent in NSCLC, with higher values in squamous cell carcinomas. SUV max correlated positively and statistically with negativity for p16 INK4a , which could explain why higher estimates of SUV max are found in squamous cell carcinomas when com- pared to adenocarcinomas. Only the clinical stage was found to be an independent prognostic value after multivariate analysis.

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非小细胞肺癌患者F-18 FDG-PET最大标准化摄取值与p16INK4a免疫表达呈负相关

我们研究了49例非小细胞肺癌(NSCLC)患者中p16 INK4a的免疫组化表达与F-18氟脱氧葡萄糖正电子发射断层扫描(F-18 FDG- PET)的最大标准化摄取值(SUV max)之间的可能关系。71.4%的患者p16 INK4a免疫组化阴性，鳞状细胞癌高于腺癌(p: 0.033)。p16 INK4a阴性组的SUV max值(17.3±8.3)高于p16 INK4a阳性组(12.7±5.2)，与p16 INK4a阴性相关(p: 0.042)。我们可以得出结论，p16 INK4a基因失活在非小细胞肺癌中非常常见，在鳞状细胞癌中更高。SUV max与p16 INK4a的负性呈正相关，这可以解释为什么在鳞状细胞癌中发现的SUV max比腺癌高。多因素分析后发现，只有临床分期是一个独立的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The open pathology journal

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