Micellar properties and solubilization of cholesterol in aqueous binary mixed solutions consisting of sodium cholate and non-ionic surfactant

Colloids and Surfaces Pub Date : 1992-11-09 DOI:10.1016/0166-6622(92)80303-J

M. Ueno, H. Asano, N. Gotoh, S. Uchida, H. Sasamoto

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引用次数: 8

Abstract

The micellar properties and behavior of cholesterol solubilization in aqueous binary mixed solutions of sodium cholate (NaC) and octaoxyethylene glycol mono n-decyl ether (C₁₀E₈) were studied by examination of the composition of the mixed micelles, polarities of the micelle interior, mean aggregation number and saturated amounts of the solubilized cholesterol in the mixed solutions. The mole fraction of NaC in the mixed micelles near the CMC was found to be less than that in aqueous mixed solution. The hydrophobicity of the interior of the mixed micelles increased with the mole fraction of NaC in the mixed solution, and the mean aggregation number abruptly decreased in the range of the low mole fraction of NaC. The saturated amount of the solubilized cholesterol in the mixed solution depends on the mean aggregation number of mixed micelles. The cholesterol solubilization behavior, studied by thermodynamic analysis, was similar to the variation of the hydrophobicity of the mixed micelles.

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胆固醇在由胆酸钠和非离子表面活性剂组成的二元水混合溶液中的胶束性质和增溶作用

通过测定混合胶束的组成、胶束内部极性、平均聚集数和溶解胆固醇的饱和量，研究了胆酸钠(NaC)和八氧基乙二醇单正癸基醚(C10E8)二元混合溶液的胶束性质和胆固醇的增溶行为。在CMC附近的混合胶束中，NaC的摩尔分数小于水溶液中的摩尔分数。混合胶束内部的疏水性随着NaC摩尔分数的增加而增加，平均聚集数在NaC低摩尔分数范围内急剧下降。混合溶液中溶解胆固醇的饱和量取决于混合胶束的平均聚集数。热力学分析表明，胆固醇的增溶行为与混合胶束的疏水性变化相似。

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Colloids and Surfaces

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