Effect of Tramadol on Hormones and Lipid Peroxidation of male Rabbits

Abstract

Tramadol manhandle straightforwardly impacts the discharge of luteinizing hormone and follicular stimulating g hormone from the front pituitary organ that diminishes the common discharge of luteinizing hormone in a pulsatile way, resulting in a negative impact on male testiclesdue to lower levels of testosterone hormone. Animals were orally given 40 mg/kg B.W. doses of tramadol. The tried measurements were given to rabbits each other day for 6 weeks. Tramadol significantly decreased body weight (BW), weight of brain, testes, testosterone, estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), triiodothyronine (T3) and thyroxin hormone (T4). While, it caused significant increase in thiobarbituric acid-reactive substances (TBARS) concentrations in plasma, testes and brain. Keywords: Tramadol; Hormone; TBARS; Rabbits