Systematic Review and Meta-Analysis of the Effects of Soy on Glucose Metabolism in Patients with Type 2 Diabetes.

Q3 Medicine

Review of Diabetic Studies Pub Date : 2019-01-01 Epub Date: 2019-10-24 DOI:10.1900/RDS.2019.15.60

Soheil Soltanipour, Tolou Hasandokht, Robabeh Soleimani, Marjan Mahdavi-Roshan, Mir Mohammad Jalali

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引用次数: 8

Abstract

Objective: This study aimed to assess the effects of soy consumption on glucose metabolism in patients with type 2 diabetes.

Methods: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review (PRISMA) principles. Literature published between 1990 and 2019 was searched. Primary outcomes were the effect of soy on fasting plasma glucose (FPG), insulin, and HbA1c. The data were pooled using random effects models. Heterogeneity was assessed using Cochran's Q and I² statistics. Also, the Cochrane Collaboration's tool for assessing risk of bias was used, and sensitivity analysis and meta-regression were conducted. Publication bias was evaluated using Egger and Begg tests.

Results: Sixteen randomized clinical trials (RCTs) with a total of 471 participants were regarded as eligible and included in the study. Soy consumption had no significant effects on FPG, insulin, and HbA1c. After the "trim-and-fill" method was applied, soy revealed a significant effect size on FPG (adjusted Cohen's d: -0.18; p = 0.03). Also, subgroup analyses using studies with parallel design showed a significant improvement (moderate effect size) in FPG and insulin. Sensitivity analysis indicated the robustness of our findings. Among secondary outcomes, the results showed a significant effect of soy on HOMA-IR and total cholesterol levels.

Conclusions: Although this systematic review and meta-analysis indicated no beneficial effects of soy consumption on FPG, insulin, and HbA1c in patients with type 2 diabetes, pooling of parallel studies showed different results from crossover studies. The quality of evidence revealed low levels of confidence for primary outcomes. Therefore, further research is recommended.

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大豆对 2 型糖尿病患者血糖代谢影响的系统性回顾和荟萃分析。

目的：本研究旨在评估食用大豆对 2 型糖尿病患者糖代谢的影响：本研究旨在评估食用大豆对 2 型糖尿病患者糖代谢的影响：根据系统性综述首选报告项目（PRISMA）原则进行了系统性综述。检索了 1990 年至 2019 年间发表的文献。主要结果是大豆对空腹血浆葡萄糖（FPG）、胰岛素和 HbA1c 的影响。采用随机效应模型对数据进行了汇总。使用 Cochran's Q 和 I2 统计量评估异质性。此外，还使用了 Cochrane 协作组织的偏倚风险评估工具，并进行了敏感性分析和元回归。使用 Egger 和 Begg 检验对发表偏倚进行了评估：共有 16 项随机临床试验（RCT）符合条件并被纳入研究，参与人数共计 471 人。食用大豆对 FPG、胰岛素和 HbA1c 没有明显影响。采用 "修剪-填充 "方法后，大豆对 FPG 有显著影响（调整后的 Cohen's d：-0.18；P = 0.03）。此外，利用平行设计研究进行的亚组分析显示，大豆对 FPG 和胰岛素有显著改善（中等效应大小）。敏感性分析表明我们的研究结果是可靠的。在次要结果中，结果显示大豆对 HOMA-IR 和总胆固醇水平有显著影响：尽管这项系统综述和荟萃分析表明，食用大豆对 2 型糖尿病患者的 FPG、胰岛素和 HbA1c 没有益处，但将平行研究汇总后发现，交叉研究的结果有所不同。证据质量显示，主要结果的可信度较低。因此，建议开展进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Review of Diabetic Studies Medicine-Internal Medicine

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.