Preparation and Evaluation of Hydrogel Alginate Beads of Rifaximin

Abstract

Any optimal medication delivery system provides a therapeutic amount of medicine to the correct spot in the body to achieve quick reaction and maintain the desired drug concentration. Intravenous drug infusion at the site of action over a desired time period can provide this optimal drug delivery. In recent years, scientists and engineers have developed rate-controlled oral medication delivery devices. These formulations provide the medicine at a controlled and predetermined rate, keeping its therapeutically effective concentration in circulation. Most restricted substances are pills. After carrying out the drug release of prepared hydrogel alginate microbeads, it was discovered that the drug release (%) was found to be in the range of 0.81 to 4.81% for the time period of 03 hours. This finding was made possible by the fact that the drug release (%) was found to be in the range of 0.81 to 4.81%. According to the data on drug release, it was discovered that the batch of fz4 had the highest sustained drug release in comparison to the other batches. According to the pattern of drug release, the rate of drug release slows down as the concentration of polymer in the formulation increases. This formulation prolongs medication release, increasing bioavailability and therapeutic activity. Sodium alginate micro beads with a release modifier could be employed as a medication carrier. The industrial-scale process needs a pilot study.