Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst

Abstract

In this work, we have reported the preparation of pyrano[2,3-d]pyrimidine dione derivatives by the tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives at the presence of isonicotinic acid as an efficient organocatalyst.