Different Drugs in Modulating Gut Microbiome of Colitis Mice

Abstract

Inflammatory Bowel Disease (IBD) is the term used to describe chronic intestinal inflammatory conditions, including Ulcerative Colitis (UC) and Crohn’s Disease (CD). While IBD is especially common among western populations, the incidence of IBD in China has increased rapidly in recent years because of the widely adopted westernized lifestyle [1]. The etiology and pathogenesis of IBD are not fully understood, and effective therapeutics are lacking. A healthy, balanced intestinal microbiome plays a key role in maintaining whole-body homeostasis. Significant alterations to the gut microbiome, referred to as dysbiosis, are present in most chronic inflammatory disease. Intestinal dysbiosis is a defining feature of IBD, with some even considering it to be causative. Indeed, manipulating the gut microbiome has been shown to greatly alleviate the symptoms of IBD [2]. Proand prebiotics are two Abstract