Early and late radiation complications after application of preoperative radiation therapy in complex treatment of cancer recti

Abstract

Objective. To study and assess the rates and degree of severity of early and late radiation complications in patients after application of preoperative radiation therapy in complex treatment of the patients, suffering cancer recti. Materials and methods. Analysis of the treatment results in 113 patients, suffering locally–advanced (сT3с–4N1–2M0) cancer recti, who have obtained preoperative oncotherapy in 2019–2022 yrs in the Department of Radiation Therapy of Zakarpattya Antitumoral Centre, was performed. Results. Most frequent early radiation affection was rectitis, which have occurred – in 86 (76,1%) patients of 113. Early radiation affections of the reproductive system organs were noted in 5 (4,4%) patients. Late radiation affections were registered in 9 (7,9%) patients, mostly frequent in the gut system – in 5 (4,4%) patients. Conclusion. Аnalysis of the complex treatment results, performed in 113 patients with cancer recti, have shown, that preoperative radiation therapy do not enhance the rate of occurrence of early radiation complications and hematological toxicity. The rate of early radiation affections was 76,1%, and of the late – 7,9%.