Preparation of Monomethyl Ethers of Poly(ethylene glycol)s Free of the Poly(Ethylene Glycol)

IF 2.2 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Bioactive and Compatible Polymers Pub Date : 2001-05-01 DOI:10.1106/V7G8-R36H-BX1R-647G

G. Lapienis, S. Penczek

引用次数: 16

Abstract

In this report, poly(ethylene glycol) (PEG) was quantitatively removed from commercial monomethyl ethers of PEG (MPEG) by column chromatography on silica gel on a preparative scale. Most of commercial MPEG, with molecular weights as high as 5000, and containing only up to 20% of PEG, were effectively purified by this technique. The content of PEG in MPEG obtained is comparable or even lower than that in samples of MPEG prepared by anionic polymerization of ethylene oxide under strictly controlled conditions. An analytical approach combining H1 NMR and chromatography techniques indicates that the PEG content in the chromatographically purified MPEG samples is less than 1%.

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不含聚乙二醇的聚乙二醇单甲醚的制备

本文采用硅胶柱层析的方法，在制备尺度上定量地从PEG (MPEG)的商业单甲基醚中分离聚乙二醇(PEG)。大多数分子量高达5000,PEG含量仅为20%的商用MPEG均可通过该技术得到有效纯化。所得MPEG中PEG的含量与严格控制条件下环氧乙烷阴离子聚合制得的MPEG样品中PEG的含量相当甚至更低。结合H1核磁共振和色谱技术的分析方法表明，色谱纯化的MPEG样品中的PEG含量小于1%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioactive and Compatible Polymers 工程技术-材料科学：生物材料

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).