The Effect of Herbal Medicine Supplementation on Clinical and Para-clinical Outcomes in Women With PCOS: A Systematic Review and Meta-analysis

Pub Date : 2019-09-20 DOI:10.15296/ijwhr.2019.72

Nava Ainehchi, A. Farshbaf‐Khalili, Aliyeh Ghasemzadeh, K. Hamdi, A. Khaki, E. Ouladsahebmadarek, A. Delazar, Fahimeh Bakhtyari, M. Mazandarani

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引用次数: 11

Abstract

Objectives: The aim of this study is to assess the impact of Cinnamomum verum, Mentha spicata, Zingiberene officinal on polycystic ovary syndrome (PCOS) treatment. Materials and Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Scopus, Web of Science, Google Scholar, ProQuest, Clinicaltrial.gov, and for Persian articles SID, Magiran, Irandoc, and Iranmedex were searched without any time limitation. Results: Thirteen randomized controlled trials (RCTs) consisting 668 women were entered in the meta-analysis. Significant differences in fasting blood sugar (FBS; weighted mean difference (WMD)=-3.69 mg/dL, 95% CI: -6.67 to -0.7, P=0.02; 241 participants), fasting insulin (WMD=-4.53 µIU/mL, 95% CI: -6.45 to -2.61, P<0.001;183 participants), triglyceride (TG; WMD=-17.97 mg/ dL, 95% CI: -30.51 to -5.43, P=0.005;183 participants), total cholesterol (TC; WMD=-14.60 mg/dL, 95% CI: -22.93 to -6.26, P=0.0006; 183 participants), low-density lipoprotein cholesterol (LDL; WMD=-16.58 mg/dL, 95% CI -23.91 to -9.24, P<0.001; 183 participants), malondialdehyde (MDA; WMD=-0.25 nmol/ml, 95% CI -0.41 to -0.09, P<0.002;124 participants), total testosterone (TT; WMD=-0.18 ng/mL, 95% CI -0.27 to -0.09, P<0.001; 116 participants), free testosterone (FT; WMD=-5.47 pg/mL, 95% CI -8.34 to -2.61, P=0.0002;78 participants) were obtained by using cinnamon alone and herbal mixture containing cinnamon in comparison to control. Conclusions: This meta-analysis showed that cinnamon alone and herbal mixture containing cinnamon improve level of FBS, fasting insulin, TG, TC, LDL, MDA, TT, and FT serum level.

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草药补充对女性多囊卵巢综合征临床和准临床结局的影响:系统回顾和荟萃分析

目的:探讨莪术、薄荷、生姜提取物对多囊卵巢综合征(PCOS)的治疗作用。材料和方法:检索MEDLINE、Cochrane中央对照试验注册中心(Central)、EMBASE、Scopus、Web of Science、Google Scholar、ProQuest、Clinicaltrial.gov，检索波斯语文章SID、Magiran、Irandoc和Iranmedex，没有任何时间限制。结果:13项随机对照试验(RCTs)包括668名妇女纳入meta分析。空腹血糖(FBS;加权平均差(WMD)=-3.69 mg/dL, 95% CI: -6.67 ~ -0.7, P=0.02;空腹胰岛素(WMD=-4.53 μ IU/mL, 95% CI: -6.45 ~ -2.61, P<0.001;183名受试者)、甘油三酯(TG;WMD=-17.97 mg/ dL, 95% CI: -30.51 ~ -5.43, P=0.005;183名参与者)，总胆固醇(TC;WMD=-14.60 mg/dL, 95% CI: -22.93 ~ -6.26, P=0.0006;183名参与者)，低密度脂蛋白胆固醇(LDL;WMD=-16.58 mg/dL, 95% CI为-23.91 ~ -9.24,P<0.001;183名参与者)，丙二醛(MDA;WMD=-0.25 nmol/ml, 95% CI -0.41 ~ -0.09, P<0.002;124名受试者)，总睾酮(TT;WMD=-0.18 ng/mL, 95% CI为-0.27 ~ -0.09,P<0.001;116名参与者)，游离睾酮(FT;WMD=-5.47 pg/mL, 95% CI -8.34至-2.61,P=0.0002;78名参与者)，分别使用肉桂和含有肉桂的草药混合物与对照组相比。结论:本荟萃分析显示，单独肉桂和含肉桂合剂可提高FBS水平、空腹胰岛素、TG、TC、LDL、MDA、TT和FT血清水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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