Efektivitas Ekstrak Etanol Akar Bajakah Merah (Spatholobus littoralis hassk) sebagai Antimalaria secara In Vitro terhadap Plasmodium falciparum

Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems Pub Date : 2022-04-11 DOI:10.20527/ht.v5i1.5214

Sinta Anisa, Erida Wydiamala, Lisda Hayatie

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Abstract

Abstract: Malaria is also called vector born disease because it is transmitted through vectors. The potential vector of this disease is the Anopheles sp. This study aimed to test the effectiveness of the ethanol extract of the red bajakah root (Spatholobus littoralis hassk) as an antimalarial in vitro against Plasmodium falciparum. This research is an experimental study with Posttest Only with Control Group Design and consists of 6 treatment groups: 5 extract concentrations, namely concentrations of 0,391 μg/ml, 0,781 μg/ml, 1,562 μg/ml, 3,125 μg/ml, 6,25 μg/ml and a solution DMSO as a negative control. The treatment was carried out with 3 replications. Based on the results of research and data processing, the ethanolic extract of the red bajakah root (Spatholobus littoralis hassk) has effectiveness as an antimalarial against Plasmodium falciparum with an IC50 value of14,877 g/ml which is included in the active category. Keywords : antimalaria, red bajakah root, Plasmodium falciparum Abstrak: Malaria disebut juga vector born disease dikarenakan penularannya melalui vektor. Vektor potensial dari penyakit ini adalah nyamuk Anopheles sp. Penelitian ini bertujuan untuk menguji efektivitas ekstrak etanol akar bajakah merah (Spatholobus littoralis hassk) sebagai antimalaria secara in vitro terhadap Plasmodium falciparum. Penelitian ini merupakan studi eksperimental dengan Posttest Only with Control Group Design dan terdiri dari 6 kelompok perlakuan: 5 konsentrasi ekstrak yaitu konsentrasi 0,391 μg/ml, 0,781 μg/ml, 1,562 μg/ml, 3,125 μg/ml, 6,25 μg/ml dan larutan DMSO sebagai kontrol negatif. Perlakuan dilakukan dengan 3 kali replikasi. Berdasar hasil penelitian dan pengolahan data ekstrak etanol akar bajakah merah (Spatholobus littoralis hassk) memiliki efektivitas sebagai antimalaria terhadap Plasmodium falciparum dengan nilai IC50 sebesar 14.877 μg/ml yang termasuk dalam kategori aktif. Kata-kata kunci : antimalaria, akar bajakah merah, Plasmodium falciparum

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红钢根乙醇(哈斯斯克的软化叶)提取物的作用，作为一种体外抗疟疾药，对等离子体有害

摘要:疟疾也被称为病媒生疾病，因为它是通过病媒传播的。该疾病的潜在传播媒介是按蚊。本研究旨在检测红巴加根乙醇提取物对恶性疟原虫的体外抗疟作用。本研究采用后测+对照组设计的实验研究，共设6个处理组:5个提取物浓度，分别为0.391 μg/ml、0.781 μg/ml、1562 μg/ml、3125 μg/ml、6、25 μg/ml，并以DMSO溶液为阴性对照。试验进行3个重复。根据研究结果和数据处理，红巴加根乙醇提取物对恶性疟原虫具有有效的抗疟作用，IC50值为14877 g/ml，属于活性类。关键词:抗疟药;红巴卡根;恶性疟原虫;媒介物潜势达氏疟蚊属、疟蚊属、疟蚊属、疟蚊属、疟蚊属、疟蚊属、疟蚊属、疟蚊属Penelitian ini merupakan某eksperimental dengan期末测验只与对照组设计丹terdiri达里语6 kelompok perlakuan: 5 konsentrasi ekstrak yaitu konsentrasi 0391μg / ml, 0781μg / ml, 1562μg / ml, 3125μg / ml, 6日25μg / ml丹larutan DMSO sebagai kontrol负数。Perlakuan dilakukan dengan 3 kali replikasi。Berdasar hasil penelitian danpengolahan数据分析，etanol akar bakakah merah (Spatholobus littoralis hask) memiliki ektivitas sebagai抗疟药(hahadap)登革热恶性疟原虫IC50 sebesar 14.877 μg/ml yang termasuk dalam kategori aktif。抗疟疾，疟疾，恶性疟原虫

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Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems

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