AN OVERVIEW ON ALLERGIC REACTIONS TO PATHOGENIC VACCINES

Sarya Hawam, A. Abou-elmagd, Mohamed Elshishtawy, T. Morsy
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Abstract

A pathogen is a bacterium, virus, parasite or fungus that inhabits virtually every environment on the planet and can cause diseases to man, animals and plants. Vaccines contain weakened or inactive parts of a particular organism (antigen) that triggers an immune response within the body. Newer vaccines contain the blueprint for producing antigens rather than the antigen itself. Regardless of whether the vaccine is made up of the antigen itself or the blueprint so that the body will produce the antigen, which will not cause the disease in the person receiving the vaccine, but it will prompt the immune system to respond much as it would have on its first reaction to the actual pathogen. They help to create protective antibodies-proteins help in fighting off infections. But, vaccine refusal may result in vaccine-preventable disease in individual and/or outbreaks of vaccine-preventable disease in unvaccinated and vaccinated individuals However, severe allergic reactions to vaccines are rare but do occur. Local reactions involved redness, swelling or irritation at the injection site. These common reactions typically begin within a few hours of the injection and clear up soon after. Systemic ones, which are less common, but potentially more serious develop sneezing, nasal congestion or hives or even throat swelling, wheezing or chest tightness. Anaphylaxis is a rare life-threatening reaction to allergy shots as low blood pressure and trouble breathing begins within 30 minutes of the injection, or even starts later than that. The vast majority of microbes are harmless, and many play essential roles in plant, animal and human health . This overview focuses on immediate-type allergic reactions to human vaccines; and delayed reactions are also briefly discussed overview discussed. The overview on allergic reactions to the new developed parasitic vaccines will be given in due time elsewhere
病原性疫苗的过敏反应综述
病原体是一种细菌、病毒、寄生虫或真菌,几乎存在于地球上的每一个环境中,并可能导致人类、动物和植物的疾病。疫苗含有特定生物体(抗原)的弱化或无活性部分,可在体内引发免疫反应。较新的疫苗包含产生抗原的蓝图,而不是抗原本身。不管疫苗是由抗原本身还是蓝图组成的,所以身体会产生抗原,这不会导致接种疫苗的人患病,但它会促使免疫系统做出反应,就像它对实际病原体的第一次反应一样。它们有助于产生保护性抗体——帮助抵抗感染的蛋白质。但是,拒绝接种疫苗可能导致个体出现疫苗可预防的疾病和/或未接种疫苗和接种疫苗的个体出现疫苗可预防疾病的暴发。然而,对疫苗的严重过敏反应很少见,但确实会发生。局部反应包括注射部位的红肿或刺激。这些常见的反应通常在注射后几小时内开始,很快就会消失。不太常见,但可能更严重的是打喷嚏、鼻塞或荨麻疹,甚至喉咙肿胀、喘息或胸闷。过敏反应是一种罕见的危及生命的过敏反应,因为在注射后30分钟内就会出现低血压和呼吸困难,甚至更晚。绝大多数微生物是无害的,许多微生物在植物、动物和人类健康中起着至关重要的作用。本综述侧重于对人类疫苗的立即型过敏反应;并对延迟反应进行了简要讨论。对新开发的寄生虫疫苗的过敏反应的概述将在适当的时候在其他地方给出
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