Adjuvant Hypo Fractionated Whole Breast Radiation therapy: A Review of Literature from Bench to Clinic

Abstract

late-Abstract Adjuvant Radiotherapy (RT) is an essential part of Breast cancer treatment with proved survival advantage . Although its radiobiological and clinical advantage becoming a standard of care practice in most centers, Hypofractionation (HF) still of a concern in certain clinical situations. Treatment Protocols are still variable across the ocean and worldwide. With the recent publications of the extreme hypofractionation we have a wide range of evidence-based protocols. This is a review of radiobiological bases and current evidence for hypofractionation in breast cancer radiation therapy starting from the basic science base up to the most recent studies.