Infection and Burn Injury

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-02-22 DOI:10.3390/ebj3010014

Edward J. Kelly, Mary A. Oliver, B. Carney, J. Shupp

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引用次数: 9

Abstract

Burn injury is debilitating and among one of the most frequently occurring traumas. Critical care improvements have allowed for increasingly positive outcomes. However, infection, whether it be localized to the site of the wound or systemic in nature, remains a serious cause of morbidity and mortality. Immune suppression predisposes the burn population to the development of invasive infections; and this along with the possibility of inhalation injury puts them at a significant risk for mortality. Emerging multi-drug-resistant pathogens, including Staphylococcus aureus, Enterococcus, Pseudomonas, Acinetobacter, Enterobacter, and yeast spp., continue to complicate clinical care measures, requiring innovative therapies and antimicrobial treatment. Close monitoring of antimicrobial regimens, strict decontamination procedures, early burn eschar removal, adequate wound closure, proper nutritional maintenance, and management of shock and resuscitation all play a significant role in mitigating infection. Novel antimicrobial therapies such as ultraviolet light, cold plasma and topical antiseptics must continue to evolve in order to lower the burden of infection in burn.

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感染和烧伤

烧伤使人衰弱，是最常见的创伤之一。重症监护的改善使得结果越来越积极。然而，感染，无论是局限于伤口部位还是全身性的，仍然是发病率和死亡率的一个严重原因。免疫抑制使烧伤人群易发生侵袭性感染;这加上吸入性损伤的可能性使他们面临很大的死亡风险。新出现的多重耐药病原体，包括金黄色葡萄球菌、肠球菌、假单胞菌、不动杆菌、肠杆菌和酵母菌，继续使临床护理措施复杂化，需要创新疗法和抗菌治疗。密切监测抗菌方案、严格的去污程序、早期清除烧伤痂、适当的伤口闭合、适当的营养维持以及休克和复苏管理都在减轻感染方面发挥着重要作用。新型抗菌疗法如紫外线、冷等离子体和局部抗菌剂必须继续发展，以降低烧伤感染的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.