Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function

Q4 Medicine

Journal of Clinical and Translational Endocrinology: Case Reports Pub Date : 2022-03-01 DOI:10.1016/j.jecr.2022.100107

Tomohiko Asada , Minoru Iwata , Shigeru Matsuzaki , Hiroshi Hamakawa , Satoru Sengan , Toshifumi Noguchi , Kazushi Daimon , Naoki Matsumura , Morikazu Shibasaki , Tetsushi Tsujimoto , Ken Ooi , Hidenao Fukuyama

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Abstract

We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed severe paradoxical reduction in serum 25-OH vitamin D levels. The serum levels of 1, 25-(OH) ₂ vitamin D, parathyroid hormone, and renal function parameters were normal. Therefore, we examined the renal reabsorption of calcium and phosphate and found a mild increase in both. The serum levels of calcium and phosphate might be determined by 1, 25-(OH) ₂ vitamin D-mediated excessive renal reabsorption of calcium and phosphate in alcoholics with 25-OH vitamin D deficiency but normal renal function.

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肾功能正常的酒精患者高钙血症和高磷血症与25-OH维生素D缺乏相关

我们提出的情况下，55岁的女性患者与酒精相关的肝损害谁提出了高钙血症和高磷血症，但也显示严重的矛盾降低血清25-OH维生素D水平。血清1,25 -(OH) 2维生素D、甲状旁腺激素及肾功能指标均正常。因此，我们检查了肾脏对钙和磷酸盐的重吸收，发现两者都有轻微的增加。25-OH维生素D缺乏但肾功能正常的酗酒者血清钙和磷酸盐水平可通过1,25 -(OH) 2维生素D介导的钙和磷酸盐的过度肾重吸收来测定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical and Translational Endocrinology: Case Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： The journal publishes case reports in a variety of disciplines in endocrinology, including diabetes, metabolic bone disease and osteoporosis, thyroid disease, pituitary and lipid disorders. Journal of Clinical & Translational Endocrinology Case Reports is an open access publication.