Hypoglycemic and Hypolipidemic Activities of Momordica dioica Roxb Fruit Pulp Extracts on Alloxan-Induced Diabetic Rats

International journal of health research and innovation Pub Date : 2010-06-09 DOI:10.4314/IJHR.V2I2.55422

K. Ilango, G. Maharajan, S. Narasimhan

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引用次数: 18

Abstract

Purpose: To investigate the effect of Momordica dioica fruit pulp extract on blood glucose and other biochemical parameters on alloxan-induced diabetic rats. Methods: Diabetes was induced in adult albino Wistar rats by intra peritoneal (ip) injection of alloxan (150 mg/kg). Hexane extract (HE) and ethyl acetate soluble fraction of methanolic extract (EASFME) of M. dioica fruit pulp (400 mg/kg) were administered as a single dose per day to the diabetes rats for 15 days. The control group received distilled water for the same duration. Blood glucose levels and serum lipid profiles were measured in the diabetic and non-diabetic rats. Results: In the diabetic rats, the elevated blood glucose levels, total cholesterol and triglycerides were reduced to the normal values by both HE and EASFME of M. dioica. Conclusion: M. dioica fruit pulp possesses antihyperglycemic and anti-lipidemic effects. The present investigation of this plant established pharmacological evidence to support the folklore claim that it is an anti-diabetic agent. Keywords: Alloxan; Hypoglycemia; Hypolipidemic; Momordica dioica.

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苦瓜果肉提取物对四氧嘧啶诱导的糖尿病大鼠的降血糖和降血脂作用

目的:探讨苦瓜果肉提取物对四氧嘧啶诱导的糖尿病大鼠血糖等生化指标的影响。方法:采用腹腔注射四氧嘧啶(150 mg/kg)诱导成年白化Wistar大鼠糖尿病。以糖尿病大鼠为研究对象，每天单次给药薯蓣果肉己烷提取物(HE)和乙酸乙酯醇提取物(EASFME) (400 mg/kg)，连续15 d。对照组给予相同时间的蒸馏水。测定了糖尿病大鼠和非糖尿病大鼠的血糖和血脂水平。结果:糖尿病大鼠的血糖、总胆固醇、甘油三酯均降至正常水平。结论:薯蓣果浆具有降血糖、降脂作用。目前对这种植物的调查建立了药理学证据，以支持民间传说它是一种抗糖尿病剂。关键词:四氧嘧啶;低血糖症;降血脂药;Momordica dioica。

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International journal of health research and innovation

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