Impact of herbs on immunomodulation in diabetes mellitus

Abstract

Diabetes mellitus, is one of the metabolic disorders mainly impairs the immune system of the body. DM is mainly as an autoimmune disease, & affects the immune system of the diseased by this disease. This is the main hindrance, which leads to various infectious diseases. It destroys the pancreatic Langerhans β cells of Islet of Langerhans of pancreatic by antigen-antibody reaction of CD4+, CD8+,T cells and auto antibodies. The prevalence of diabetes and its complications are rising worldwide alarmingly. Now around 143 million of the world population is affected from diabetes.1 This will be doubled in 2030.2 One of the major concern in case of Diabetes is decrease in cell immunity which results into various complication’s. Immuno modulators are group of medicines or diet supplements which increase the immunity by increasing the production of various immune stimulating agents like interferons.etc. There are many plants having a role in diabetes management. Experimental and clinical trials have shown the efficacy of plant and its constituents play an important role in the management of impaired immunity in diabetes. Interestingly, the results of experimental studies on diabetic physiological molecular pathways.3 Immunomodulation helps impaired immune system response in case of immunosuppression like Diabetes, Rheumatoid arthritis, HIV etc. We have highlighted in this study the efficacious plants with their bioactive molecules are responsible for immunomodulatory action in diabetes. Indian flora consists about 45,000 plant species,4 in which three thousand plants used in the various traditional system of medicines and folk lore medicine of India.