Silylation of piroxicam with some silylating reagents, and characterization of them to improve some properties of this drug

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Main Group Chemistry Pub Date : 2022-04-20 DOI:10.3233/mgc-220036

M. Galehassadi, Somayeh Jodeiri, E. Rezaii

引用次数: 0

Abstract

In this work, we synthesized some organosilicon derivatives of piroxicam. Due to some properties of organosilicon compounds, including increased lipophilicity and thermal stabilization and prodrug for drugs, some silyl ethers of this drug were synthesized and characterized. Increasing of the lipophilic properties of this drug can be very important in the rate of absorption and its effectiveness. We synthesized silyl ethers of this drug, in the next step some copolymers this drug was synthesized. All of compounds were identified by spectroscopic methods.

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吡罗昔康与一些硅化试剂的硅化反应，并对其进行表征以改善该药物的某些性能

在这项工作中，我们合成了一些吡罗西康的有机硅衍生物。由于有机硅化合物的亲脂性、热稳定性和药物的前药性等特性，合成并表征了该药物的一些硅醚。增加该药物的亲脂性对其吸收率和有效性非常重要。我们合成了该药物的硅醚，在下一步合成了该药物的一些共聚物。所有化合物都通过光谱方法进行了鉴定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Main Group Chemistry 化学-化学综合

CiteScore

2.00

自引率

26.70%

发文量

审稿时长

>12 weeks

期刊介绍： Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.