Ex-vivo Antimalarial and in-vitro Biological Activities of newly synthesized Co(II) complex with Schiff base

Abstract

The first-row transition metal complex of Schiff base has been synthesized and characterized based on physicochemical spectral and biochemical methods. The metal-ligand stoichiometry and molecular formula of the complex assessed by Elemental analysis and metal estimation-neutral, monomeric nature of the complex and paramagnetic nature also predict by the conductance and magnetic moment study. The octahedral environment around Co(II) and metal-imine bond as a whole predicted by atomic IR and Far-IR spectra. In-vitro antibacterial and antifungal activities of the Schiff base and its complexes compared with those for standard (Chloramphenicol & Fluconazole) by agar disc diffusion method. The Ex-vivo antimalarial activity of the Schiff base and its metal complex was found by using Plasmodium falciparum bacteria/fungal.