Anti-Ebola vaccination of humans using a chimeric virus: rational of a hope

Abstract

The promising ability of a recombinant vaccine to protect humans against the risk of getting infected upon contact with Ebola-sick patients comes as one of the best news from the recent devastating Ebola crisis in Western Africa [1]. This trial is built according to the ring vaccination scheme that was used in the final stage of the smallpox eradication scheme [2] (figure 1). This scheme was developed to curtail the limitations of mass vaccination and to reduce exposure to the risk of severe side [...]