Influence of surface chemistry and morphology of nanoparticles on protein corona formation

Roberta Bilardo, Federico Traldi, Alena Vdovchenko, M. Resmini
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引用次数: 30

Abstract

Abstract Nanomaterials offer promising solutions as drug delivery systems and imaging agents in response to the demand for better therapeutics and diagnostics. However, the limited understanding of the interaction between nanoparticles and biological entities is currently hampering the development of new systems and their applications in clinical settings. Proteins and lipids in biological fluids are known to complex with nanoparticles to form a “biomolecular corona”. This has been shown to affect particles' morphology and behavior in biological systems and their interactions with cells. Hence, understanding how nanomaterials' physicochemical properties affect the formation and composition of this biocorona is a crucial step. This work evaluates existing literature on how morphology (size and shape), and surface chemistry (charge and hydrophobicity) of nanoparticles influence the formation of protein corona. The latest evidence suggest that although surface charge promotes the interaction with proteins and lipids, surface chemistry plays a leading role in determining the affinity of the nanoparticle for biomolecules and, ultimately, the composition of the corona. More recently the study of additional nanoparticles' properties like shape and surface chirality have demonstrated a significant effect on protein corona architecture, providing new tools to tailor biomolecular corona formation. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
纳米颗粒表面化学和形态对蛋白质电晕形成的影响
纳米材料作为药物输送系统和显像剂提供了有前途的解决方案,以响应对更好的治疗和诊断的需求。然而,对纳米颗粒和生物实体之间相互作用的有限理解目前阻碍了新系统的发展及其在临床环境中的应用。已知生物液体中的蛋白质和脂质与纳米颗粒复合形成“生物分子日冕”。这已经被证明会影响生物系统中粒子的形态和行为以及它们与细胞的相互作用。因此,了解纳米材料的物理化学性质如何影响这种生物日冕的形成和组成是至关重要的一步。这项工作评估了关于纳米颗粒的形态(大小和形状)和表面化学(电荷和疏水性)如何影响蛋白质电晕形成的现有文献。最新的证据表明,尽管表面电荷促进了与蛋白质和脂质的相互作用,但表面化学在决定纳米颗粒对生物分子的亲和力以及最终决定电晕的组成方面起着主导作用。最近,对纳米颗粒形状和表面手性等特性的研究表明,纳米颗粒对蛋白质电晕结构有重要影响,为定制生物分子电晕形成提供了新的工具。本文分类为:治疗方法和药物发现;新兴技术;纳米医学毒理学和监管问题;b1纳米材料毒理学
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
17.60
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