Modeling the drug release from 3D multi-layer microstructure with micro-chambers

Abstract

This paper presents a mathematical model for three-dimensional biodegradable multi-layer drug delivery microstructure with large array of micro-chambers. The simultaneous release of multiple drugs from this type of drug delivery microstructure is modeled using cellular automata (CA) and discrete iterations. The model can describe the dynamic behavior of drug release. Furthermore, simulations about this type of drug delivery microstructure enclosed two drugs are carried out. The simulation results show that the introduced mathematical model can act as the basis of a new optimal design methodology for three-dimensional biodegradable multi-layer drug delivery microstructure.