Age related T2-FSE-MRI basal ganglia and inter-nuclei changes in normal aging

Q3 Medicine

Neurology Psychiatry and Brain Research Pub Date : 2019-06-01 DOI:10.1016/j.npbr.2019.03.002

Milet Mendoza , Antonio Eblen-Zajjur

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引用次数: 1

Abstract

To evaluate clinically easy to obtain parameters such as area and T2 MR signal intensity (SI) profiles from right and left caudate, putamen and thalamus nuclei and to describe age-related and inter-nuclei changes in both genders in healthy subjects, 71 healthy subjects (22–80 years old, 52 females) were evaluated with 1.5 T MRI conventional axial T2-Fast axial spin echo sequences obtaining SI and cross-sectional areas from caudate, putamen and thalamus nuclei using manually defined ROIs. Regression analysis were performed between age and MR parameters for inter-nuclei, gender and hemisphere side. Male basal ganglia show lower SI than those from females. Aging was differentially associated to a progressive lowering of basal nuclei SI in both genders. Male basal ganglia show SI changes following a positive quadratic function. Aging modifies differentially SI from all nuclei pair combination in both genders, showing mainly negative quadratic function. Age-related reduction of female caudate and a right lateralization for caudate nucleus SI in both genders were found. Healthy age-related nonlinear changes in SI from basal ganglia were defined for both genders. Basal ganglia show differential age-related changes. These results can be helpful to differentiate normal from abnormal aging changes.

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年龄相关的T2-FSE-MRI基底节区和核间区在正常衰老中的变化

为了评估临床容易获得的左右尾状核、壳核和丘脑核的面积和T2磁共振信号强度(SI)分布等参数，并描述健康受试者中男女年龄相关和核间变化，我们使用1.5 T MRI常规轴向T2- fast轴向自旋回波序列评估71名健康受试者(22-80岁，52名女性)，使用人工定义的roi获取尾状核、壳核和丘脑核的SI和横截面积。年龄与核间、性别、半球侧磁共振参数之间进行回归分析。男性基底神经节的SI低于女性基底神经节。在两性中，衰老与基底核SI的进行性降低存在差异。男性基底节区SI随正二次函数变化。年龄对男女各核对组合SI的影响存在差异，主要表现为负二次函数。发现女性尾状核的年龄相关减少和尾状核SI的右侧偏侧。定义了男女基底节区SI与健康年龄相关的非线性变化。基底神经节表现出不同年龄相关的变化。这些结果有助于区分正常和异常的衰老变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Psychiatry and Brain Research 医学-精神病学

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.