In situ synthesis of UV-responsive mesoporous SiO2 drug release systems using the associates of anionic drugs and cationic silica source as templates

IF 0.7 4区材料科学 Q4 METALLURGY & METALLURGICAL ENGINEERING

International Journal of Materials Research Pub Date : 2023-09-08 DOI:10.1557/s43578-023-01148-w

Hanxia Tang, Yuqing Xue, Zhiming Wu, Wenqian Zhu, Fengzhu Lv, Yihe Zhang

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引用次数: 0

Abstract

One of the major challenges in medicine is the preparation of a controlled drug release system sensitive to environmental stimuli via a simple method. In the present work, the association of ibuprofen with (3-aminopropyl) triethoxysilane (APTES) was studied in detail. Then a mesoporous SiO2 (m-SiO2) drug release systems were synthesized via the simplified sol–gel method using the associates of ibuprofen and APTES as templates. Also, the m-SiO2 were in situ modified by UV-responsive groups to fabricate particles sensitive to pH and UV stimulus. On–off release behaviors were realized by further association of UV-responsive groups of the particles with β-cyclodextrins. Although slight harm of the particles to Gram-negative E. coli was observed due to the introduction of UV-responsive groups, it could be overcome by slight enlargement of the particle size. Therefore, the fabricated m-SiO2 particles were smart drug release systems.

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以阴离子药物和阳离子二氧化硅源为模板物的紫外响应介孔二氧化硅药物释放系统的原位合成

利用一种简单的方法制备对环境刺激敏感的可控药物释放系统是医学领域面临的主要挑战之一。本文详细研究了布洛芬与(3-氨基丙基)三乙氧基硅烷(APTES)的缔合反应。然后以布洛芬和APTES为模板物，采用简化溶胶-凝胶法合成了介孔SiO2 (m-SiO2)释药体系。同时，利用紫外响应基团对m-SiO2进行原位修饰，制备出对pH值和紫外刺激敏感的颗粒。通过与β-环糊精进一步结合uv响应基团，实现了颗粒的开关释放行为。虽然由于引入了紫外线反应基团，观察到颗粒对革兰氏阴性大肠杆菌的轻微伤害，但可以通过稍微扩大颗粒大小来克服。因此，制备的m-SiO2颗粒是一种智能药物释放系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Materials Research 工程技术-冶金工程

CiteScore

1.30

自引率

12.50%

发文量

119

审稿时长

6.4 months

期刊介绍： The International Journal of Materials Research (IJMR) publishes original high quality experimental and theoretical papers and reviews on basic and applied research in the field of materials science and engineering, with focus on synthesis, processing, constitution, and properties of all classes of materials. Particular emphasis is placed on microstructural design, phase relations, computational thermodynamics, and kinetics at the nano to macro scale. Contributions may also focus on progress in advanced characterization techniques. All articles are subject to thorough, independent peer review.