{"title":"Serum biochemical changes in fighter pilots before and after plateau training","authors":"H. Xue, X. Zhu, Hong Xue, Weidong Li","doi":"10.3760/CMA.J.ISSN.1007-6239.2015.01.008","DOIUrl":null,"url":null,"abstract":"Objective \nTo evaluate the influence of plateau hypoxia environment on the parameters of liver, renal, cardiac and metabolic functions of fighter pilots, and provide the basis for the high altitude aeromedical service. \n \n \nMethods \nSerum biochemical indices were examined and compared among 35 fighter pilots before and after 3-month high altitude training by automatic biochemistry analyzer and the results were analyzed by paired t-test. \n \n \nResults \nCompared with those before plateau training, pilots' fasting serum aspartate aminotransferase (AST), albumin (ALB), blood urea nitrogen (BUN) levels after plateau training were decreased slightly or significantly (t=2.042, 10.329, 2.275, P<0.05 or <0.01), but were still in the normal range. Direct bilirubin (DBIL), creatinine (Cr), Beta2-microglobuline (β2-MG), lactate dehydrogenase (LDH), creatinine kinase (CK), total cholesterol (TC) were significantly higher than those before the training (t=3.792-12.454, P<0.01), but were basically in the normal range or approaching to upper limits; uric acid (UA) was significantly higher than that before training and the normal (t=4.373, P<0.01); alanine aminotransferase (ALT), total bilirubin (TBIL), total protein (TP), cystatin C (Cys C), glucose (Glu), triglycerides (TG) levels did not change significantly. \n \n \nConclusions \nThis study elucidated that high altitude environment can affect pilot's partial liver, renal, cardiac and metabolic functions. So the preventive measures should be strengthened. \n \n \nKey words: \naltitude; liver function tests; kidney function tests; uric acid; pilots","PeriodicalId":9904,"journal":{"name":"中华航空航天医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华航空航天医学杂志","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2015.01.008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
To evaluate the influence of plateau hypoxia environment on the parameters of liver, renal, cardiac and metabolic functions of fighter pilots, and provide the basis for the high altitude aeromedical service.
Methods
Serum biochemical indices were examined and compared among 35 fighter pilots before and after 3-month high altitude training by automatic biochemistry analyzer and the results were analyzed by paired t-test.
Results
Compared with those before plateau training, pilots' fasting serum aspartate aminotransferase (AST), albumin (ALB), blood urea nitrogen (BUN) levels after plateau training were decreased slightly or significantly (t=2.042, 10.329, 2.275, P<0.05 or <0.01), but were still in the normal range. Direct bilirubin (DBIL), creatinine (Cr), Beta2-microglobuline (β2-MG), lactate dehydrogenase (LDH), creatinine kinase (CK), total cholesterol (TC) were significantly higher than those before the training (t=3.792-12.454, P<0.01), but were basically in the normal range or approaching to upper limits; uric acid (UA) was significantly higher than that before training and the normal (t=4.373, P<0.01); alanine aminotransferase (ALT), total bilirubin (TBIL), total protein (TP), cystatin C (Cys C), glucose (Glu), triglycerides (TG) levels did not change significantly.
Conclusions
This study elucidated that high altitude environment can affect pilot's partial liver, renal, cardiac and metabolic functions. So the preventive measures should be strengthened.
Key words:
altitude; liver function tests; kidney function tests; uric acid; pilots
期刊介绍:
The aim of Chinese Journal of Aerospace Medicine is to combine theory and practice, improve and popularize, actively advocate a hundred flowers bloom and a hundred schools of thought contend, advocate seeking truth from facts, promote the development of the related disciplines of aerospace medicine and human efficiency, and promote the exchange and penetration of aerospace medicine and human efficiency with other biomedical and engineering specialties.
Topics of interest for Chinese Journal of Aerospace Medicine include:
-The content of the journal belongs to the discipline of special medicine and military medicine, with the characteristics of multidisciplinary synthesis and cross-penetration, and mainly reflected in the aerospace industry, aerospace flight safety and efficiency, as well as the synthesis of special medicine, preventive medicine, environmental medicine, psychology, etc.
-Military aeromedicine (Air Force, Navy and Army aeromedicine) and civil aeromedicine, with a balance of aerospace medicine are the strengths of the journal.
-The change in aerospace medicine from a focus on promoting physiological compensatory adaptations to enhancing human performance under extreme environmental conditions is what the journal is helping to promote.
-The expansion of manuscripts in high altitude medicine is also a special emphasis of the journal.